益生菌联合美沙拉嗪治疗溃疡性结肠炎的疗效分析

行亚峰1 ，雷晓民2

（渭南市合阳县人民医院：1.内一科；2.内二科，陕西 渭南，715300）

浏览次数：280次 下载次数：320次

摘要：

目的 分析益生菌联合美沙拉嗪治疗溃疡性结肠炎的临床疗效。方法 将我院收治的110例溃疡性结肠炎患者随机分为对照组和观察组，各55例。对照组患者使用美沙拉嗪口服治疗，观察组患者予以益生菌联合美沙拉嗪治疗，两组患者均用药2个疗程，对比两组患者的治疗效果、不良反应情况及治疗前、后的血清C-反应蛋白水平。结果 观察组的治疗总有效率 高于对照组（P<0.05）。两组的不良反应总发生率比较，无明显差异（P<0.05）。治疗后8 周、治疗后6个月随访的两组的血清 C-反应蛋白水平均较治疗前降低，且观察组的C-反应蛋白水平低于对照组（P<0.05），但治疗后8周、治疗后6个月随访两组组内的血清C-反应蛋白水平无明显差异（P>0.05）。结论 益生菌联合美沙拉嗪治疗溃疡性结肠炎的疗效优于单独使用美沙拉嗪的治疗效果，应在临床进行推广。

关键词：益生菌；美沙拉嗪；溃疡性结肠炎；C-反应蛋白

中图分类号：R574.62 文献标志码：A文章编号：2096-1413(2017)14-0022-02

Efficacy of probiotics combined with misalazine in the treatment of ulcerative colitis
XING Ya-feng 1, LEI Xiao-min 2
(1. 1st Department of Medicine; 2. 2nd Department of Medicine, People`s Hospital of Heyang County,

 Weinan 715300, China)

ABSTRACT: Objective To analyze the clinical effect of probiotics combined with mesalazine in the treatment of patient with ulcerative colitis. Methods One hundred and ten cases of patient with ulcerative colitis in our hospital were randomly divided into control group and observation group, with 55 cases in each group. The control group were treated with mesalazine, while the observation group were given probiotics combined with mesalazine, the two groups were treated for two courses. The treatment efficiency, adverse reactions and serum C-reactive protein levels before and after treatment in the two groups were compared. Results The total effective rate in the observation group was higher than that of the control group (P<0.05). There was no significant difference of the incidence of adverse reactions of the two groups (P>0.05). After treated for 8 weeks and 6 months follow-up, the levels of the C-reactive protein in the two groups decreased, the levels of the C-reactive protein in the observation group were lower than those of the control group (P<0.05), but there were no significant difference in the levels of the C-reactive protein between after treated for 8 weeks and 6 months follow-up in the two groups (P>0.05). Conclusion The efficacy of probiotics combined with mesalazine in the treatment of patient with ulcerative colitis is superior to that of mesalazine alone, and it should be popularized in clinical.
KEYWORDS: probiotics; mesalazine; ulcerative colitis; C-reactive protein

参考文献：
[1] 刘勇,谭瑞明.益生菌联合美沙拉嗪治疗溃疡性结肠炎的临床疗效观察[J].吉林医学,2010,31(15):2228-2230.
[2] 刘闻莺,丘洪,李英梅,等.益生菌联合美沙拉嗪治疗轻中度溃疡性结肠炎的临床疗效[J].中国临床医学,2013,20(2):150-151,156.
[3] 许永春,冯青青,李春安,等.美沙拉嗪联合益生菌治疗溃疡性结肠炎临床观察[J].南昌大学学报:医学版,2016,56(3):47-49.
[4] 张诒凤,张豹,崔姗姗,等.益生菌治疗轻中度溃疡性结肠炎的疗效观察[J].泰山医学院学报,2015,36(6):604-607.
[5] 王海英.美沙拉嗪联合益生菌治疗轻中度溃疡性结肠炎疗效观察[J].陕西医学杂志,2013,42(7):921-922.
[6] 宋海霞.酪酸梭菌活菌胶囊联合美沙拉嗪治疗溃疡性结肠炎的疗效及安全性观察[J].临床医药文献电子杂志,2016,3(7):1351,1354.