氯吡格雷联合阿司匹林对进展性脑梗死患者的临床观察
张鹏飞
（陕西省宝鸡市岐山县医院神经内科，陕西 宝鸡，722400）
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摘要：
目的 探讨氯吡格雷联合阿司匹林对进展性脑梗死患者的临床疗效。方法 选择2012年1月至2015年12月收治的120例进展性急性脑梗死患者，根据随机数字表法，分为观察组及对照组，每组60例。两组均给予常规治疗，对照组在常规治 疗基础上给予阿司匹林，观察组给予氯吡格雷联合阿司匹林，观察两组患者治疗前及治疗1、2、3 个疗程后的NIHSS 评分及 Barthel指数，观察两组患者的不良反应发生情况。结果 与治疗前相比，两组患者治疗1、2、3个疗程后的NIHSS评分均明显 下降（P<0.05），而观察组在治疗1、2、3个疗程后的NIHSS评分均明显低于对照组（P<0.05）。治疗1、2、3 个疗程后观察组患 者的Barthel指数评分均明显高于对照组（P<0.05）。两组患者的不良反应发生情况比较无明显差异（P>0.05）。结论 氯吡格雷 联合阿司匹林可以显著改善进展性脑梗死患者的预后，且安全性较高，值得临床推广应用。
关键词：氯吡格雷；阿司匹林；进展性脑梗死；预后
中图分类号：R743.32文献标志码：A文章编号：2096-1413(2016)25-0112-02
Clinical observation of clopidogrel combined with aspirin in patients with progressive cerebral infarction
ZHANG Peng-fei
(Department of Neurology, Qishan County Hospital, Baoji 722400, China)
ABSTRACT: Objective To investigate the clinical efficacy of clopidogrel combined with aspirin in patients with progressive cerebral infarction. Methods From January 2012 to December 2015, 120 patients with progressive acute cerebral infarction were selected and divided into observation group and control group, with 60 cases in each group. Two groups were given conventional therapy, the control group received aspirin and the observation group received aspirin and clopidogrel. The NIHSS score, Barthel index, adverse reactions were observed before and after treatment between the two groups. Results Compared with before treatment, the NIHSS scores of the two groups were decreased after 1, 2 and 3 courses of treatment (P<0.05), and the score of the observation group was higher than that of the control group after treatment (P<0.05). The Barthel index score of the observation group was significantly higher than that of the control group after 1, 2 and 3 courses of treatment (P<0.05). The adverse reactions of the two groups were not statistically significant (P>0.05). Conclusion Clopidogrel combined with aspirin can significantly
improve the prognosis of patients with progressive cerebral infarction, which is worthy of clinical application.
KEYWORDS: clopidogrel; aspirin; progressive cerebral infarction; prognosis
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