氨茶碱与喷托维林治疗老年睡眠呼吸暂停综合征的效果对比

罗晓琴，张红娟

（宝鸡市中心医院，陕西 宝鸡，721008）

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摘要：

目的 研究比较氨茶碱与喷托维林治疗老年睡眠呼吸暂停综合征（OSHAS）的临床效果。方法 选取2015年1月至2016年8月我院收治的100例老年OSHAS患者作为研究对象，随机分为A、B两组，每组50例。两组患者均给予临床常规治疗， 在此基础上，A组患者给予氨茶碱治疗，B组患者给予喷托维林治疗，比较两组患者的临床总有效率、MSaO₂、睡眠呼吸障碍维持时间、呼吸暂停低通气指数及药物不良反应发生率。结果 A组患者的临床总有效率为96.00%，B组为92.00%，组间比 较，差异无统计学意义（P>0.05）。治疗后，两组患者的MSaO₂ 均较治疗前明显增高，睡眠呼吸障碍维持时间、呼吸暂停低通气指数均明显减少，差异有统计学意义（P<0.05），两组患者治疗后各指标及药物不良反应发生率比较，差异均无统计学意义（P>0.05）。结论 采用氨茶碱、喷托维林治疗老年睡眠呼吸暂停综合征均具有显著的疗效和安全性，可有效缓解患者的睡眠 呼吸障碍。

关键词：睡眠呼吸暂停综合征；氨茶碱；喷托维林；安全性

中图分类号：R766文献标志码：A文章编号：2096-1413(2017)18-0025-02

Effect comparison of aminophylline and pentoxyverine in elderly patients with sleep apnea syndrome
LUO Xiao-qin, ZHANG Hong-juan
(Baoji Central Hospital, Baoji 721008, China)

ABSTRACT: Objective To study and compare the clinical effect of aminophylline and pentoxyverine in elderly patients with sleep apnea syndrome (OSHAS). Methods One hundred elderly patients with sleep apnea syndrome admitted in our hospital from January 2015 to August 2016 were selected and randomly divided into group A and group B, with 50 cases in each group. All the patients were given clinical routine treatment, and group A added aminophylline, while group B added pentoxyverine. The total effective rate, MSaO₂, sleep apnea maintain time, apnea hypopnea index and drug adverse reactions of the two groups were compared. Results The total effective rate of the group A was 96.00%, and that of the group B was 92.00%, the difference between the two groups was not statistically significant (P>0.05). After treatment, the levels of MSaO₂ of the two groups increased compared with those before treatment, and the sleep apnea maintain time and apnea hypopnea index decreased, the differences were statistically significant (P<0.05). There were no significant differences on the indexes after treatment and drug adverse reactions between the two groups (P>0.05). Conclusion Aminophylline and pentoxyverine in elderly patients with sleep apnea syndrome both have significant clinical effects and safety, which can effectively alleviate the patients`` sleep apnea.
KEYWORDS: sleep apnea syndrome (OSHAS); aminophylline; pentoxyverine; safety

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