克拉霉素联合三联疗法治疗幽门螺杆菌感染胃炎的临床效果

汪博

（陕西省宝鸡市陈仓医院，陕西 宝鸡，721300）

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摘要：

目的 对克拉霉素联合三联疗法治疗幽门螺杆菌感染胃炎的临床疗效进行探讨。方法 从我院消化内科2013年9月至 2016年9月收治的幽门螺杆菌感染胃炎患者中选取220 例作为研究对象，采用随机数字表法分为对照组和观察组，各110例。对照组患者给予传统三联疗法治疗，观察组患者给予克拉霉素联合三联疗法治疗，比较两组患者临床治疗效果、幽门螺杆菌根除率和不良反应发生情况。结果 观察组患者治疗总有效率为96.36%，高于对照组的78.18%，差异具有统计学意义（P<0.05）；观察组患者幽门螺杆菌根除率为100.00%，高于对照组的80.91%，差异具有统计学意义（P<0.05）；观察组患者不良反应发生率为10.91%，对照组为13.64%，两组比较，差异无统计学意义（P>0.05）。结论 对幽门螺杆菌感染胃炎患者实施克拉霉素联合三联疗法，能够获得理想的临床效果，幽门螺杆菌清除率高，同时安全性较高，值得临床应用。

关键词：克拉霉素；三联疗法；幽门螺杆菌感染胃炎

中图分类号：R573.3文献标志码：A文章编号：2096-1413(2017)18-0029-02

Clinical effect of clarithromycin combined with triple therapy in the treatment of helicobacter

pylori-associated gastritis
WANG Bo
(Chencang Hospital of Baoji, Baoji 721300, China)

ABSTRACT: Objective To discuss the clinical effect of clarithromycin combined with triple therapy in the treatment of helicobacter pylori infection in gastritis. Methods Two hundred and twenty cases of patients with helicobacter pylori -associated gastritis in our hospital from September 2013 to September 2016 were selected as the research objects, which were divided into control group and observation group according to the random digital table method, with 110 cases in each group. The control group was given conventional triple therapy, while the observation group was given clarithromycin combined with triple therapy. The clinical effect, helicobacter pylori eradication rate and adverse reactions in the two groups were compared. Results The total effective rate was 96.36% in the observation group, which was higher than 78.18% in the control group, the difference was statistically significant (P<0.05). The eradication rate of helicobacter pyloriin the observation group was 100.00%, which was higher than 80.91% in the control group, the difference was statistically significant (P<0.05). The incidence of adverse reactions in the observation group was 10.91%, in the control group was 13.64% , and there was no significant difference between the two groups (P >0.05). Conclusion For patients with helicobacter pylori -associated gastritis, the implementation of clarithromycin combined with triple therapy can achieve ideal clinical effect, the helicobacter pylori eradication rate is high, which is worthy of clinical application.
KEYWORDS: clarithromycin; triple therapy; helicobacter pylori-associated in gastritis

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