左乙拉西坦单药治疗小儿癫痫伴智力低下的临床效果研究

殷朝阳

（商洛市中心医院儿科，陕西 商洛，726000）

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摘要：

目的 研究左乙拉西坦单药治疗小儿癫痫伴智力低下的临床效果。方法 回顾性分析我院2013年5月至2016年5月收治的60例癫痫伴智力低下患儿的临床资料，全部患儿均在我院接受左乙拉西坦单药治疗，观察所有患儿在癫痫、智力方面的治疗总有效率以及治疗3、6 个月的IQ 值。结果 治疗3个月后，60例患儿的癫痫治疗总有效率为96.67%，智力治疗总有效率为93.33%。治疗3、6 个月的IQ 值明显高于治疗前，且治疗6个月的IQ值高于治疗3个月的IQ值，差异均具有统计学意义（P<0.05）。结论 在小儿癫痫伴智力低下的临床治疗中，采用左乙拉西坦单药治疗效果确切，有助于控制癫痫的发作，并促进患儿智力发育，值得在临床治疗中推广应用。

关键词：左乙拉西坦；小儿癫痫；智力低下

中图分类号：R742.1文献标志码：A文章编号：2096-1413(2017)18-0094-02

Clinical effect of levetiracetam monotherapy on children with epilepsy and mental retardation
YIN Chao-yang
(Department of Pediatrics, Shangluo Central Hospital, Shangluo 726000, China)

ABSTRACT: Objective To study the effect of levetiracetam monotherapy in the treatment of children with epilepsy and mental retardation. Methods The clinical data of 60 cases of children with epilepsy and mental retardation treated in our hospital from May 2013 to May 2016 were retrospectively analyzed. All the children were treated with levetiracetam monotherapy. The total effective rate of epilepsy, intelligence, and the IQ value of 3 and 6 months after treatment were observed in all children. Results After 3 months, the total effective rate of epilepsy in 60 cases of children was 96.67%, the total effective rate of intelligence therapy was 93.33%. The IQ value of children at 3 and 6 months after treatment were significantly higher than that before treatment, and the IQ value at 6 months was higher than that of 3 months after treatment, the differences were statistically significant (P <0.05). Conclusion The clinical effect of levetiracetam monotherapy in children with epilepsy and mental retardation is effective. It is helpful to control the seizure of epilepsy and promote the intelligence of children, which is worth popularizing in clinical treatment.
KEYWORDS: levetiracetam monotherapy; children with epilepsy and mental retardation; mental retardation

参考文献：
[1] 赵均峰,吴云,张宪坤,等.左乙拉西坦治疗小儿癫痫的疗效及不良反应[J].中国医药科学,2013,3(5):90-91.
[2] 谭婷丹.复方氨基丁酸维E 胶囊联合左乙拉西坦治疗小儿癫痫的临床疗效观察[J].中国实用神经疾病杂志,2016,19(1):120-121.
[3] 李志斌,江慧敏,肖华,等.奥卡西平联合左乙拉西坦治疗小儿癫痫的疗效及安全性[J].实用医学杂志,2016,32(16):2734-2736.
[4] 金超.左乙拉西坦治疗小儿癫痫80例及智力分析[J].中国药业,2015,24(9):14-16.
[5] 任丽峰,杜长波,赵大伟,等.丙戊酸联合卡马西平治疗小儿癫痫的效果及对认知功能的影响[J].中国当代医药,2014,21(31):85-87.
[6] 张奇.左乙拉西坦单药治疗不同类型小儿癫痫疗效与安全性观察[J].中国实用医药,2016,11(4):130-131.
[7] 武运红,韩虹,唐宇辉,等.左乙拉西坦口服液单药治疗婴儿期癫痫临床分析及随访研究[J].中国药物与临床,2015,15(1):121-122.
[8] 王建,周刚.左乙拉西坦对小儿癫痫患者认知功能的影响[C]//急诊医学临床学术探讨研究会,北京:2016.
[9] 周定富,刘日阳,林俊荣,等.左乙拉西坦单药治疗小儿癫痫伴智力低下的临床价值分析[J].现代诊断与治疗,2015,26(11):2432-2433.
[10] 陈明,李松,林海峰,等.左乙拉西坦单药在小儿癫痫治疗中的安全性及可行性分析[J].包头医学院学报,2015,29(7):32-33.