NT-ProBNP检测对充血性心力衰竭预后评估的意义
高海燕
（陕西省陇县人民医院，陕西 宝鸡，721200）
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摘要：
目的 探讨N 端脑钠肽前体（NT-ProBNP）检测对充血性心力衰竭预后评估的意义。方法 选择2015年1月至12月我院收治的500例充血性心力衰竭患者为研究对象，根据美国心脏病协会（NYHA）分级标准将所有患者分为Ⅰ~Ⅱ级组（n= 148）、III 级组（217 例）和IV 级组（135 例）。所有患者一入院便行NT-ProBNP检测，动态观察三组患者入院至出院期间的 NT-ProBNP水平变化情况和近期出现的不良心脏事件。结果 Ⅳ级组患者入院时的NT-proBNP 水平显著高于Ⅰ~Ⅱ级组与 Ⅲ级组，差异有统计学意义（P<0.05）；三组在住院治疗期间NT-proBNP 水平均逐渐降低，出院时的NT-proBNP 水平显著低 于入院时（P<0.05）。Ⅳ级组住院期间的不良心脏事件发生率与死亡率均显著高于Ⅰ~Ⅱ级组与Ⅲ级组（P<0.05）。结论 对于充血性心力衰竭患者，通过检测NT-ProBNP水平可为临床医生判断其近期预后提供参考。
关键词：NT-ProBNP；充血性心力衰竭；预后
中图分类号：R541.6文献标志码：A文章编号：02096-1413(2017)19-0007-02
The significance of NT-ProBNP test in evaluating the prognosis of patients with congestive heart failure
GAO Hai-yan
(People``s Hospital of Long County, Baoji 721200, China)
ABSTRACT: Objective To investigate the significance of NT-ProBNP test in evaluating the prognosis of patients with congestive heart failure. Methods Five hundred patients with congestive heart failure treated in our hospital from January to December 2015 were selected as study objects, and divided into group I - II (n=148), group III (n=217) and group IV (n=135) according to American Heart Association (NYHA). The level of NT-ProBNP was detected as soon as patients ad mitted. The changes of NT-ProBNP levels and the recent adverse events were observed in the three groups during admission to discharge. Results The level of NT-proBNP in group Ⅳ was significantly higher than those of group Ⅰ~Ⅱ and group Ⅲ at admission (P<0.05); NT-proBNP levels were gradually decreased in the three groups during hospitalization, and NT-proBNP levels at discharge were significantly lower than those at admission (P<0.05). The incidence rate of adverse cardiac events and mortality of group Ⅳ were significantly higher than those of group Ⅰ~Ⅱ and group Ⅲ (P<0.05). Conclusion For patients with congestive heart failure, NT-ProBNP levels can be detected by the clinician to provide a reference for their short-term prognosis.
KEYWORDS: NT-ProBNP; congestive heart failure; prognosis
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