不同疗程糖皮质激素治疗重症COPD急性加重期的疗效及安全性

李彩霞

（吴起县人民医院，陕西 延安，717600）

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摘要：

目的 探讨不同疗程糖皮质激素治疗重症COPD 急性加重期患者的疗效及安全性。方法 选取我院收治的180例重症COPD急性加重期患者，随机分为短程治疗组和常规治疗组，各90例，分别给予不同疗程的糖皮质激素进行治疗。对两组患者的临床疗效，治疗前、后肺功能及动脉血气分析指标和不良反应发生率进行比较。结果 两组患者临床疗效比较，差异无统 计学意义（P>0.05）。治疗前，两组患者肺功能及动脉血气分析指标比较，差异无统计学意义（P>0.05）；治疗后两组患者肺功能、动脉血气分析指标均显著改善（P<0.05），但两组间比较差异无统计学意义（P>0.05）。短程治疗组不良反应总发生率低于常规治疗组，差异有统计学意义（P<0.05）。结论 与短程糖皮质激素治疗相比，常规治疗方案增加了不良反应发生率，因此，对重症COPD急性加重期患者应尽可能实施短疗程的糖皮质激素治疗。

关键词：不同疗程；糖皮质激素；重症COPD 急性加重期

中图分类号：R563.9 文献标志码：A文章编号：2096-1413(2017)19-0035-02

Efficacy and safety of different courses of glucocorticoid therapy in acute exacerbation of severe COPD
LI Cai-xia
(People``s Hospital of Wuqi County, Yan``an 717600, China)


ABSTRACT: Objective To investigate the efficacy and safety of different course of glucocorticoid therapy in acute exacerbation of severe COPD. Methods One hundred and eighty patients with severe acute exacerbation of COPD in our hospital were selected and randomly divided into conventional treatment group and short course group, with 90 cases in each group, and different courses of glucocorticoid were administered respectively. The clinical efficacy, pulmonary function and arterial blood gas analysis index before and after treatment and adverse reactions of the two groups were compared. Results There was no significant difference in the clinical curative effect between the two groups (P>0.05). There were no significant differences in pulmonary function and arterial blood gas analysis between the two groups before treatment (P>0.05); after treatment, the pulmonary function and arterial blood gas analysis indexes of the two groups significantly improved (P<0.05), but there were no significant differences between the two groups (P>0.05). The incidence of adverse reactions in the short course group was lower than that in the conventional treatment group (P<0.05). Conclusion Compared with the short course of glucocorticoid, the conventional treatment increases the incidence of adverse reactions. So patients with severe acute exacerbation of COPD should be treated with short course of glucocorticoid as far as possible.
KEYWORDS: different course of treatment；glucocorticoid；severe acute exacerbation of COPD

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