依达拉奉治疗急性脑出血的临床效果及安全性

成巧梅

（陕西省富县中医医院药剂科，陕西 渭南，727500）

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摘要：

目的 观察依达拉奉治疗急性脑出血的临床效果及安全性。方法 将78例我院收治的急性脑出血患者采用随机数表法分为对照组和观察组，每组39例。对照组采用常规对症支持治疗，观察组在常规治疗的基础上给予依达拉奉治疗。比较两组治疗效果，治疗前、后的NO、SOD、LPO、GP水平及治疗过程中不良反应发生情况。结果 两组治疗14 d 后，观察组患者的临床总有效率达94.87%，显著高于对照组的76.92%（P<0.05）。两组治疗前的NO、SOD、LPO、GP水平比较，无显著差异（P>0.05）；治疗14 d 后，两组的NO、LPO水平显著低于治疗前，SOD、GP水平明显高于治疗前，且观察组的上述指标均优于对照 组（P<0.05）。两组不良反应发生率比较，无显著差异（P>0.05）。结论 依达拉奉治疗急性脑出血临床效果显著，可有效清除氧自由基，不良反应少，值得临床推广应用。

关键词：依达拉奉；急性脑出血；NO；SOD；LPO；GP

中图分类号：R743.3文献标志码：A文章编号：2096-1413(2017)20-0037-02

Clinical effect and safety of edaravone on acute cerebral hemorrhage
CHENG Qiao-mei
(Department of Pharmacy, Traditional Chinese Medicine Hospital of Fu 悦ounty, Weinan 727500, China)

ABSTRACT: Objective To observe the clinical effect and safety of edaravone on acute cerebral hemorrhage. Methods Seventy eight cases of patients with acute cerebral hemorrhage were divided into control group and observation group according to the random table method, with 39 cases in each group. The control group used conventional support treatment, while the observation group added edaravone on the basis of the conventional support treatment, the treatment effects, NO, SOD, LPO, GP levels before and after treatment and adverse reactions were compared in the two groups. Results After 12 d treatment, the total effective rate of the observation group was 94.87%, which was significantly higher than 76.92% of the control group (P<0.05). Before treatment, there were no significant differences in the NO, SOD, LPO, GP levels between the two groups (P>0.05). After 12 d treatment, the NO, LPO levels in the two groups were lower than those before treatment, while SOD, GP levels were higher than those before treatment, those indexes in the observation group were better than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Edaravone has remarkable effect on acute cerebral hemorrhage, which can effectively clear away oxygen free radicals, and has less adverse reactions, it is worthy of clinical application.
KEYWORDS: edaravone; acute cerebral hemorrhage; NO; SOD; LPO; GP

参考文献：
[1] 陈勇,高林,常娜,等.依达拉奉治疗脑出血的临床疗效观察[J].中国实用神经疾病杂志,2008,11(6):104-105.
[2] 李登星.依达拉奉治疗脑出血的疗效观察[J].临床神经病学杂志,2009,22(3):224-226.
[3] 沈琪琦,张之龄,童小文,等.依达拉奉治疗急性脑出血的疗效分析[J].中国临床保健杂志,2016,19(1):19-21.
[4] 朱东铭,罗成宏,崔玉真.依达拉奉治疗高血压脑出血的临床疗效研究[J].国际医药卫生导报,2006,12(13):88-89.
[5] 丁进京.依达拉奉联合醒脑静治疗急性脑出血的疗效观察[J].中国实用神经疾病杂志,2012,15(7):55-57.
[6] 黄承红,蔡志友,曾令琼,等.依达拉奉对脑出血患者血清IL-1β、 TNF-α影响的研究[J].重庆医学,2008,37(7):728-729.
[7] 王景英.依达拉奉对急性脑出血患者自由基含量的影响及临床疗效观察[J].当代医学,2010,16(20):12-13.
[8] 陈岩,郑境効,方向,等.依达拉奉对急性脑出血患者血浆S-100β蛋白表达及神经功能的影响[J].临床神经病学杂志,2012,25(5):385-387.
[9] 李雷,刘冰,李万斌,等.依达拉奉对急性脑出血患者ICAM-1 和 MMP-9的影响作用[J].中风与神经疾病杂志,2010,27(5):436-438.