氯吡格雷与拜阿斯匹林联合治疗急性冠脉综合征的疗效及安全性评价

孙文科

（周至县中医院，陕西 西安，710400）

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摘要：

目的 评价氯吡格雷与拜阿斯匹林联合治疗急性冠脉综合征的疗效及安全性。方法 随机选取2013年3月至2016年 3月我院收治的急性冠脉综合征患者80例，依据治疗方法将其分为氯吡格雷与拜阿斯匹林的联合治疗组和拜阿斯匹林的单独治疗组，每组40 例。对两组患者的临床疗效、胸痛发作频率和持续时间、肌钙蛋白含量、心血管事件发生情况进行统计分析。结果 联合治疗组患者治疗的总有效率显著高于单独治疗组（P<0.05）。治疗前，两组患者的胸痛发作频率、胸痛持续时间、肌钙蛋白含量比较，差异均无统计学意义（P>0.05）；治疗后，两组患者的胸痛发作频率、肌钙蛋白含量均显著低于治疗前（P<0.05），胸痛持续时间显著短于治疗前（P<0.05），且联合治疗组患者的胸痛发作频率、肌钙蛋白含量均显著低于单独治疗组（P<0.05），胸痛持续时间显著短于单独治疗组（P<0.05）。联合治疗组患者的心血管事件总发生率显著低于单独治疗组（P< 0.05）。结论 氯吡格雷与拜阿斯匹林联合治疗急性冠脉综合征安全有效。

关键词：氯吡格雷；拜阿斯匹林；急性冠脉综合征

中图分类号：R541文献标志码：A文章编号：2096-1413(2017)26-0018-02

Efficacy and safety evaluation of clopidogrel combined with aspirin worship in the treatment

of acute coronary syndrome
SUN Wen-ke
(Zhouzhi County Hospital of Traditional Chinese Medicine, Xi``an 710400, China)

ABSTRACT: Objective To evaluate the efficacy and safety of clopidogrel combined with aspirin worship in the treatment of acute coronary syndrome. Methods Eighty cases of patients with acute coronary syndrome in our hospital from March 2013 to March 2016 were randomly selected and divided into combined treatment group (clopidogrel combined with aspirin worship, n=40) and single treatment group (aspirin worship, n=40) according to the treatment methods. The clinical efficacy, the frequency and duration of chest pain and troponin content, the occurrence of cardiovascular events of the two groups were statistically analyzed. Results The total effective rate of combined treatment group was significantly higher than that of single treatment group(P<0.05). Before treatment, there was no significant difference in the frequency and duration of chest pain, and the troponin content between the two groups (P>0.05). After treatment, the frequency of chest pain and troponin levels in the two groups were significantly lower than those before treatment (P<0.05), and the duration of chest pain was significantly shorter than that before treatment (P<0.05); the frequency of chest pain and troponin levels in the combined treatment group were significantly lower than those in the single treatment group (P<0.05), and the duration of chest pain was significantly shorter than that in the single treatment group (P <0.05). The total cardiovascular event rate was significantly lower than the single treatment group (P<0.05). Conclusion Clopidogrel combined with aspirin worship is safe and effective in the treatment of acute coronary syndrome.
KEYWORDS: clopidogrel; aspirin worship; acute coronary syndrome

参考文献：
[1] 张亚玲.氯吡格雷联合阿司匹林治疗急性冠脉综合征的临床价值 [J].中国药物经济学,2014,9(4):72-73.
[2] 李明哲,吴强.替格瑞洛在行PCI 治疗的急性心肌梗死患者中的临床疗效和安全性观察[J].海南医学院学报,2014,20(11):1492-1495.
[3] 李秀芬,葛振嵘,许力舒,等.替格瑞洛联合小剂量替罗非班对急性非ST段抬高心肌梗死患者纤维蛋白原的影响[J].中华老年心脑血管病杂志,2015,17(4):429-430.
[4] 李江,刘文娴,赵一楠,等.替格瑞洛在治疗氯吡格雷抵抗患者时血小板聚集率分析[J].中国全科医学,2014,17(19):2231-2234.
[5] 石俊松.氯吡格雷联合阿司匹林治疗急性冠脉综合征临床疗效评价[J].九江学院学报:自然科学版,2014,29(3):83-84.
[6] 张冰.氯吡格雷与阿司匹林联合方案治疗急性心肌梗死临床疗效分析[J].航空航天医学杂志,2014,25(2):221-222.
[7] 蔡英博.氯吡格雷治疗急性冠脉综合征的临床效果分析[J].中国继续医学教育,2015,7(16):149-150.