曲美布汀联合多塞平、培菲康治疗慢性胃肠功能紊乱的效果观察

陈金华1 ，3 ，苌新明2

（1.西安交通大学医学部，陕西 西安，710061；2.西安交通大学第一附属医院消化内科, 陕西 西安，710061； 3.西北工业大学医院，陕西 西安，710072）

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摘要：

目的 观察慢性胃肠功能紊乱应用曲美布汀、多塞平、培菲康联合治疗的效果。方法 随机将在本院治疗的104例慢性胃肠功能紊乱患者分为研究组和对照组，每组52例，研究组给予曲美布汀、多塞平、培菲康联合治疗，对照组给予谷维素、多塞平、培菲康联合治疗，观察两组患者的临床治疗效果、临床症状消失时间及不良反应发生情况。结果 研究组的治疗总有效率（96.2%）高于对照组（82.7%）（P<0.05）；研究组上腹痛、腹胀、早饱、嗳气、恶心等症状消失时间均短于对照组（P<0.05）；两组患者不良反应发生率比较，差异不显著（P>0.05）。结论 慢性胃肠功能紊乱应用曲美布汀、多塞平、培菲康联合治疗时，效果良好，不良反应少。

关键词：曲美布汀；多塞平；培菲康；慢性胃肠功能紊乱

中图分类号：R57文献标志码：A文章编号：2096-1413(2017)26-0030-02

Effect observation of trimebutine combined with doxepin and bifico on chronic gastrointestinal dysfunction
CHEN Jin-hua 1, 3, CHANG Xin-ming 2
(1. Department of Medical, Xi``an Jiaotong University, Xi``an 710061; 2. Department of Gastroenterology, the First Affiliated Hospital of
Xi``an Jiaotong University, Xi``an 710061; 3. Northwestern Polytechnical University Hospital, Xi``an 710072, China)

ABSTRACT: Objective To observe the effect of trimebutine combined with doxepin and bifico in the treatment of chronic gastrointestinal disorders. Methods One hundred and four patients with chronic gastrointestinal disorders were randomly divided into study group and control group, with 52 cases in each group. The study group was given trimebutine combined with doxepin and bifico treatment, and the control group was given oryzanol combined with doxepin and bifico treatment. The clinical effect, disappearance time of clinical symptoms and adverse reactions were observed in the two groups. Results The total effective rate of the study group (96.2%) was higher than that of the control group (82.7%) (P<0.05). The
disappearance times of clinical symptoms such as abdominal pain, abdominal distension, early satiety, belching, nausea in the study group were shorter than those in the control group (P<0.05). There was no significant difference between the two groups in the incidence rate of adverse reactions (P>0.05). Conclusion The trimebutine, doxepin and bifico has a good therapeutic effect and few adverse reactions chronic gastrointestinal disorders .
KEYWORDS: trimebutine; doxepin; bifico; chronic gastrointestinal dysfunction

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