普罗布考联合阿托伐他汀、阿司匹林治疗颈动脉粥样硬化斑块60例疗效观察

赵景安，聂世刚，茹超

（陕西省咸阳市三原县医院，陕西 咸阳，713800）

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摘要：

目的 观察普罗布考联合阿托伐他汀、阿司匹林治疗动脉粥样硬化斑块的疗效。方法 将120 例颈动脉粥样硬化斑块患者随机分为对照组和研究组，每组60例。给予对照组患者常规治疗，研究组患者在常规治疗的基础上给予普罗布考联合阿 托伐他汀、阿司匹林治疗，观察两组的治疗效果及用药期间出现的不良反应。结果 治疗前，两组患者的颈动脉IMT、颈动脉内膜斑块面积、各项血脂水平、hs-CRP 和ox-LDL水平比较，差异均不具有统计学意义（P>0.05）；治疗后，两组患者的上述指标均显著优于治疗前，且研究组患者优于对照组（P<0.05）。两组患者治疗过程中均未出现明显不良反应。结论 普罗布考联合阿 托伐他汀、阿司匹林治疗颈动脉粥样硬化斑块的疗效显著，安全性高，具有临床推广价值。

关键词：普罗布考；阿托伐他汀；阿司匹林；粥样硬化斑块

中图分类号：R743.3文献标志码：A文章编号：2096-1413(2017)28-0039-02

Efficacy observation of probucol combined with atorvastatin and aspirin in the treatment of 60 cases of carotid atherosclerotic plaques
ZHAO Jing-an, NIE Shi-gang, RU Chao
（Sanyuan County Hospital, Xianyang 713800, China）

ABSTRACT: Objective To observe the efficacy of probucol combined with atorvastatin and aspirin in the treatment of carotid atheromatous plaques. Methods A total of 120 cases of patients with carotid atheromatous plaques were randomly divided into control group and research group, with 60 cases in each group. Patients in the control group were given traditional treatment, while patients in the research group treated with the combination of probucol, atorvastatin and aspirin based on the traditional treatment. The curative effect and the adverse reactions of the two groups during the period of treatment were compared. Results Before treatment, there were no significant differences in carotid IMT, carotid intimal plaque area, blood lipid levels, hs-CRP and ox-LDL levels between the two groups (P>0.05). After treatment, the above indexes of the two groups were significantly better than those before treatment, and those in the research group were significantly better than the control group (P<0.05). No obvious adverse symptoms were observed in the two groups during the treatment. Conclusion Probucol combined with atorvastatin and aspirin is effective and safe in the treatment of carotid atherosclerotic plaque, which is worthy of clinical application.
KEYWORDS: probucol; atorvastatin; aspirin; carotid atheromatous plaques

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