布地奈德阶梯雾化联合干扰素治疗小儿急性感染性喉炎的疗效分析
强春梅
（陕西省延安市宜川县人民医院，陕西 延安，716200）
浏览次数：89次 下载次数：347次
摘要：
目的 探讨布地奈德阶梯雾化联合干扰素治疗小儿急性感染性喉炎的疗效。方法 选择2013年8月至2015年12月在我院治疗的120例急性感染性喉炎患儿作为研究对象，随机将其分为观察组与对照组，各60例，对照组患儿给予布地奈德阶梯雾化治疗，观察组患儿给予布地奈德阶梯雾化联合干扰素治疗，两组均治疗5 d，记录两组患儿的临床效果。结果 观察 组患儿的治疗总有效率显著高于对照组，差异具有统计学意义（P<0.05）；观察组患儿呼吸困难、声嘶、发热、咳嗽消失时间明 显短于对照组（P<0.05）。结论 布地奈德阶梯雾化联合干扰素治疗小儿急性感染性喉炎能有效缩短临床症状消失时间，提高治疗效率，可作为急性感染性喉炎的规范化治疗方法。
关键词：布地奈德；阶梯雾化；干扰素；小儿急性感染性喉炎
中图分类号：R767.1文献标志码：A文章编号：2096-1413(2017)28-0083-02
Efficacy analysis of budesonide ladder atomization combined with interferon in children with acute infectious laryngitis
QIANG Chun-mei
(Yichuan County People``s Hospital, Yan``an 716200, China)
ABSTRACT: Objective To investigate the efficacy of budesonide ladder atomization combined with interferon in the treatment of acute infectious laryngitis. Methods From August 2013 to December 2015, 120 cases of children with acute infectious laryngitis in our hospital were enrolled and randomly divided into observation group and control group, with 60 cases in each group. The control group was given budesonide ladder atomization, and the observation group was given budesonide ladder atomization combined with interferon. All the patients were treated for 5 days, and the prognosis of children in the two groups were recorded. Results The total effective rate of the observation group was significantly higher than that of the control group, the difference between the two groups was significant (P<0.05). The disappeared time of hoarseness, dyspnea, fever and cough symptoms in the observation group were significantly shorter than those in the control group (P<0.05). Conclusion Budesonide ladder atomization combined with interferon in the treatment of acute infectious laryngitis can effectively shorten the disappeared time of clinical symptoms, improve treatment effect, which can be used as a treatment standard in children with acute infectious laryngitis.
KEYWORDS: budesonide; ladder atomization; interferon; acute infective laryngitis
参考文献：
[1] 李晓娜,李玉杰,黄炜,等.布地奈德对小儿感染性喉炎的疗效及 IL-4、IFN-γ 和IgE 水平的影响[J].中国妇幼保健,2015,30(30):5194-5196
[2] 杨晓霞,李忠义.肾上腺素联用布地奈德雾化吸入治疗小儿急性感染性喉炎喉梗阻的疗效观察[J].吉林医学,2015,58(6):1089-1090.
[3] 薛国昌,任明星,周静月,等.感染性喉炎和痉挛性喉炎患儿血清中IL-4、IFN-γ 和IgE 水平检测的临床意义[J].新医学,2014,45(1):49-52.
[4] 任明星,薛国昌,周静月,等.痉挛性喉炎患儿血清白细胞介素-4、γ干扰素和免疫球蛋白E 水平变化的意义[J].中华实用儿科临床杂志,2014,29(4):286-288.
[5] 施弦.布地奈德联合干扰素雾化吸入治疗小儿急性感染性喉炎疗效分析[J].浙江中医药大学学报,2012,36(5):529-531.
[6] 吴瑞萍,胡亚美,江载芳.实用儿科学[M].7版.北京:人民卫生出版社,2002:1162-1164.
[7] 强瑞雪,谢春奇,周艳.布地奈德联合干扰素氧气驱动雾化吸入治疗小儿急性喉炎疗效观察[J].医学信息(下旬刊),2009,1(6):91-98.
[8] 慕继霞.不同方式治疗小儿急性感染性喉炎的临床效果观察[J].河南医学研究,2015,24(1):127.
[9] 宋玮,李献哲,尹昕,等.超声雾化吸入治疗慢性咽喉炎110例疗效观察[J].中国实用医药,2014,9(11):160.
[10] 高秀娟,刘强,滕晓茗,等.3豫高渗盐水联合利巴韦林和地塞米松超声雾化吸入治疗急性咽喉炎的疗效观察及护理[J].广西医学,2015,37(4):576-577.
[11] COOPER V,METCALF L,VERSNEL J,et al.Patient -reported side effects, concerns and adherence to corticosteroid treatment for asthma, and comparison with physician estimates of side -effect prevalence: a UK -wide, cross -sectional study [J].NPJ Prim Care Respir Med,2015,9 (25):15026-15033.