胎儿纤维连接蛋白对单双胎早产的预测价值比较

潘霞，张秀玲

（西安市西电医院妇产科，陕西 西安，710000）

浏览次数：74次 下载次数：315次

摘要：

目的 比较胎儿纤维连接蛋白（fFN）对单双胎早产的预测价值。方法 对我院收治的伴随先兆早产症状的66例单胎妊娠及76例双胎妊娠孕妇的临床资料进行回顾性分析，所有孕妇均进行fFN 测定。比较单双胎中fFN 检测结果。结果 fFN 在单胎妊娠早产预测中，阳性预测值为80.77%，阴性预测值为90.00%；灵敏度为84.00%，特异度为87.80%。在双胎妊娠早产预测中，阳性预测值为77.27%，阴性预测值为85.18%；灵敏度为68.00%，特异度为90.20%。fFN 在单双胎妊娠早产预测结果比 较，差异均无统计学意义（P>0.05）。结论 胎儿纤维连接蛋白的检测在伴随先兆早产症状的无单胎妊娠和双胎妊娠的早产筛 查中均为有效的预测指标。

关键词：先兆早产症状；单、双胎妊娠；胎儿纤维连接蛋白；早产

中图分类号：R714.23文献标志码：A文章编号：2096-1413(2017)28-0126-02

Predictive value comparison of fetal fibronectin in monocyesis and bigeminal pregnancy with symptoms of preterm birth
PAN Xia, ZHANG Xiu-ling
(Department of Obstetrics and Gynecology, Xi``an XD Group Hospital, Xi``an 710000, China)

ABSTRACT: Objective To compare the predictive value of fetal fibronectin (fFN) in monocyesis and bigeminal pregnancy with symptoms of preterm birth. Methods The clinical data of 66 pregnant women with monocyesis and 76 pregnant women with bigeminal pregnancy who had symptoms of preterm birth were retrospectively analyzed. All the pregnant women received fFN detection, and the fFN detection results of monocyesis and bigeminal pregnant women were compared. Results The positive predictive value of fFN in monocyesis with symptoms of preterm birth was 80.77%, the negative predictive value was 90.00%, the sensitivity was 84.00%, and the specificity was 87.80%. The positive predictive value of fFN in bigeminal pregnancy with symptoms of preterm birth was 77.27%, the negative predictive value was 85.18%, the sensitivity was 68.00%, and the specificity was 90.20%. The fFN detection results of monocyesis and bigeminal pregnancy women had no significant difference (P>0.05). Conclusion The fFN detection is an effective prediction index of preterm birth in both monocyesis and bigeminal pregnancy.
KEYWORDS: symptoms of preterm birth; monocyesis and bigeminal pregnancy; fetal fibronectin (fFN); preterm birth

参考文献：
[1] FUCHS F,SENAT MV.Multiple gestations and preterm birth[J].Semin Fetal Neonatal Med,2016,21(2):113-120.
[2] MAKRYDIMAS G,SOTIRIADIS A.Prediction of preterm birth in twins[J].Best Pract Res Clin Obstet Gynaecol,2014,28(2):265-272.
[3] TSOI E,AKMAL S,GEERTS L,et al.Sonographic measurement of cervical length and fetal fibronectin testing in threatened preterm labor[J]. Ultrasound Obstet Gynecol,2006,27(4):368-372.
[4] FOX NS,SALTZMAN DH,FISHMAN A,et al.Gestational Age at cervical length and fetal fibronectin assessment and the incidence of spontaneous preterm birth in twins[J].J Ultrasound Med,2015,34(6):977-984.
[5] ANANTH CV,CHAUHAN SP.Epidemiology of twinning in developed countries[J].Semin Perinatol,2012,36(3):156-161.
[6] 张曼.双胎妊娠272 例临床分析[D].济南:山东大学,2012.
[7] LOCKWOOD CJ,SENYEI AE,DISCHE MR,et al.Fetal fibronectin in cervical and vaginal secretions as a predictor of preterm delivery [J].N Engl J Med,1991,325(10):669-674.
[8] RUIZ RJ,FULLERTON J,BROWN CE.The utility of fFN for the prediction of preterm birth in twin gestations[J].J Obstet Gynecol Neonatal Nurs,2010,33(4):446-454.
[9] KURDI AM,MESLEH RA,ALHAKEEM MM,et al.Multiple pregnancy and preterm labor[J].Saudi Med J,2004,25(5):632-637.
[10] 郝静,李彦军.胎儿纤维连接蛋白联合宫颈长度检测对双胎妊娠早产的预测价值[J].临床和实验医学杂志,2016,15(14):1431-1433.
[11] 李光莲,陈丹玲.胎儿纤维连接蛋白联合宫颈长度在双胎妊娠早 产的诊断价值[J].右江民族医学院学报,2015,37(3):422-423.
[12] YEAST JD,LU G.Biochemical markers for the prediction of preterm labor[J].Obstet Gynecol Clin North Am,2005,32(3):369-381.