雷贝拉唑联合奥美拉唑治疗消化性溃疡Hp感染的疗效观察

邱爱龙

（华县中铁一局集团中心医院，陕西 渭南，714100）

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摘要：

目的 观察雷贝拉唑联合奥美拉唑治疗幽门消化性溃疡螺杆菌（Hp）感染的临床疗效。方法 选取2015年7月至2016年8月我院收治的消化性溃疡Hp 感染患者88例，将其随机分为对照组和观察组，各44例。对照组单用奥美拉唑治疗，观察组采用雷贝拉唑联合奥美拉唑治疗。比较两组临床疗效、胃液pH 值及不良反应发生率。结果 治疗2周后及治疗3个月后，观察组治疗总有效率均高于对照组（P<0.05）；观察组治疗1周后胃内pH 值为（5.73±0.12），明显高于对照组的（4.35±0.16） （P<0.05）；观察组不良反应发生率与对照组相比，差异无统计学意义（P>0.05）。结论 雷贝拉唑联合奥美拉唑能够明显降低消化性溃疡Hp感染患者胃内酸含量，提高pH值，对胃黏膜形成保护作用，降低急性胃黏膜病变的发生率。

关键词：雷贝拉唑；奥美拉唑；消化性溃疡；幽门螺杆菌

中图分类号：R573.1文献标志码：A文章编号：2096-1413(2017)30-0029-02

Efficacy of rabeprazole combined with omeprazole on peptic ulcer Hp infection
QIU Ai-long
(China Railway First Group Co.,Ltd Central Hospital of Hua County, Weinan 714100, China)

ABSTRACT: Objective To observe the clinical efficacy of rabeprazole combined with omeprazole on peptic ulcer helicobacter pylori (Hp). Methods A total of 88 patients with peptic ulcer Hp infection in our hospital from July 2015 to August 2016 were randomly divided into control group and observation group, with 44 cases in each group. The control group was given simply omeprazole treatment, the research group was given rabeprazole combined with omeprazole treatment. The clinical efficacy, pH of gastric juice and the incidence of adverse reactions of the two groups were compared. Results The total effective rates of the observation group at 2 week and 3 month after treatment were significantly higher than those of the control group (P<0.05). One week after treatment, the gastric pH of the observation group was (5.73±0.12), which was significantly higher than (4.35±0.16) of the control group (P<0.05); there was no statistical difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Rabeprazole combined with omeprazole can significantly decrease gastric acid content of peptic ulcer Hp infectious patients, increase pH, protect gastric mucosa and reduce the incidence of acute gastric mucosal lesion.
KEYWORDS: rabeprazole; omeprazole; peptic ulcer; helicobacter pylori (Hp)

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