不同剂量布地奈德雾化吸入对小儿毛细支气管炎症状的改善作用

俱永生，王小红

（志丹县人民医院儿科一病区，陕西 延安，717500）

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摘要：

目的 探讨不同剂量布地奈德雾化吸入对小儿毛细支气管炎症状的改善作用。方法 选择2014年8月至2016年8月我院收治的小儿毛细支气管炎患儿100例，随机将其分为对照组（50 例）和观察组（50例），对照组给予常规剂量布地奈德雾化吸入，观察组先给予大剂量布地奈德雾化吸入，待其症状缓解后给予常规剂量。比较两组患儿的症状、体征持续时间及住院时间，并评价治疗效果。结果 与对照组比较，观察组发热、咳嗽、憋喘、气促等临床症状消失时间，肺部哮鸣音、湿音等临床 体征消失时间及住院天数均明显较短（P<0.05）；与对照组比较，观察组患儿的治疗总有效率明显较高（P<0.05）。结论 在小儿毛细支气管炎急性期给予大剂量布地奈德雾化吸入有助于快速缓解患儿临床症状和体征，缩短病程，促进患儿早日康复出院，而在症状缓解后适时降低剂量，不仅不会影响疗效，还有助于避免潜在药物的不良反应。

关键词：不同剂量；布地奈德；小儿毛细支气管炎

中图分类号：R725.6文献标志码：A文章编号：2096-1413(2017)30-0100-02

Effect of different doses of budesonide inhalation on symptoms of bronchiolitis in children
JU Yong-sheng, WANG Xiao-hong
(the First Ward in Department of Pediatrics, Zhidan County People``s Hospital, Yan``an 717500, China)

ABSTRACT: Objective To investigate the effect of different doses of budesonide inhalation on the symptoms of bronchiolitis in children. Methods One hundred cases of patients with pediatric bronchiolitis in our hospital from August 2014 to August 2016 were selected, and randomly divided into control group (50 cases) and observation group (50 cases). The patients in the control group were given the routine dose of budesonide inhalation, the patients in the observation group were given the high dose of budesonide inhalation, and all the children were given the routine dose when the symptoms were relieved. The symptoms, signs duration time and hospitalization time of the two groups were compared, and the therapeutic effect was evaluated. Results Compared with the control group, the symptoms disappeared time of fever, cough, wheezing, shortness of breath, lung wheeze, signs disappearance time of wet rales, and hospitalization time in the observation group were significantly shorter (P<0.05); compared with the control group, the total effective rate of the observation group was significantly higher (P<0.05). Conclusion High dose of budesonide inhalation in the treatment of acute pediatric bronchiolitis is helpful for rapid remission of clinical symptoms and signs, can promote the early rehabilitation of the patients. Timely reducing dose when the symptoms are relieved can not only ensure affect efficacy, but also help to avoid potential adverse drug reactions.
KEYWORDS: different doses; budesonide; pediatric bronchiolitis

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