不同质子泵抑制剂在反流性食管炎中的临床效果对比

韩珊萍1 ，付宁2

（1.陕西省韩城市人民医院消化内科，陕西 渭南，715400；2.西安北环医院，陕西 西安，710032）

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摘要：

目的 探讨不同质子泵抑制剂在反流性食管炎中的临床效果。方法 选择2014年6月至2016年6月我院收治的反流性食管炎患者120例，以治疗方式分对照组和观察组，各60 例。对照组患者用奥美拉唑治疗，观察组患者用埃索美拉唑治疗。比 较两组患者各项试验数据。结果 治疗后，两组患者反流性食管炎症状评分低于治疗前，且观察组低于对照组（P<0.05）。观察 组临床治疗总有效率为96.67%，高于对照组的85.00%（P<0.05）；观察组患者药物不良反应总发生率为10.00%，低于对照 组的35.00%（P<0.05）。结论 埃索美拉唑短期治疗反流性食管炎的临床疗效优于奥美拉唑。

关键词：质子泵抑制剂；反流性食管炎；埃索美拉唑；奥美拉唑

中图分类号：R571文献标志码：A文章编号：2096-1413(2017)32-0032-02

Clinical effects comparison of different proton pump inhibitors in reflux esophagitis
HAN Shan-ping 1, FU Ning 2
(1. Department of Gastroenterology, Hancheng People``s Hospital, Weinan 715400；2. Xi``an Beihuan Hospital, Xi``an 710032, China)

ABSTRACT: Objective To study the clinical effects of different proton pump inhibitors in reflux esophagitis. Methods A total of 120 patients with reflux esophagitis treated in our hospital from June 2014 to June 2016 were selected and divided into control group and observation group according to treatment methods, with 60 cases in each group. The control group was treated with omeprazole, and the observation group was treated with esomeprazole; the experimental data between the two groups was compared. Results After treatment, the esophageal reflux sex inflammation scores of the two groups were lower than those before treatment, and those of the observation group were lower than control group (P<0.05); the total effective rate of clinical therapeutic in the observation group was 96.67%, which was better than 85.00% of the control group (P<0.05); the total incidence rate of adverse drug reactions in the observation group was 10.00%, which was lower than 35.00% of the control group (P<0.05). Conclusion The clinical efficacy of esomeprazole in short-term treatment of reflux esophagitis is better than that of the omeprazole.
KEYWORDS: proton pump inhibitors; reflux esophagitis; esomeprazole; omeprazole

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