不同保守治疗方案治疗异位妊娠的疗效比较
肖转琴
（韩城市妇幼保健院，陕西 渭南，715400）
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摘要：
目的 探讨不同保守治疗方案治疗异位妊娠的疗效，为异位妊娠的临床治疗提供参考依据。方法 收集2013年4月至 2016年4月我院收治的50例异位妊娠患者作为本次研究对象，按照治疗方式分为观察组和对照组，每组25例。对照组患者 采用甲氨蝶呤（MTX）50 mg/m2 单次肌肉注射，用药后每周抽血2次，动态观察血人绒毛膜促性腺激素（β-HCG）变化，如1周后血β-HCG值下降<15%或不下降反而升高，则再次注射MTX 50 mg/m2，最多2 次。观察组患者在对照组的基础上联合使用 米非司酮，空腹服用，2 次/d，比较两组患者的治疗效果。结果 观察组患者治疗总有效率（92.00%）高于对照组（72.00%）（P<0.05）；观察组血β-HCG值恢复正常时间和住院时间明显短于对照组（P<0.05）。结论MTX 联合米非司酮治疗异位妊娠 效果显著，安全可靠，患者接受度高，可在临床推广使用。
关键词：异位妊娠；甲氨蝶呤；米非司酮
中图分类号：R714.22文献标志码：A文章编号：2096-1413(2017)32-0087-02
Effects comparison of different conservative treatment methods on ectopic gestation
XIAO Zhuan-qin
(Hancheng Maternal and Child Health Care Service Center, Weinan 715400, China)
ABSTRACT: Objective To compare the efficacy of two conservative treatments for ectopic gestation, so as to provide reference for optimal treatment choice. Methods A total of 50 cases of patients hospitalized with ectopic gestation from April 2013 to April 2016 in our hospital were selected and divided into observation group and control group, with 25 cases in each group. 50 mg/m2 of methotrexate (MTX) intramuscular injection was peformed. in the control group, and blood was collected twice a week to measure the level changes of β-human chorionic gonadotrophin (β-HCG), and 50 mg/m2 of MTX was administered again a week later under the situation either β-HCG concentration decreased by 15% or increased since the first injection, up to 2 times. In the observation group, mifepristone was taken orally on empty stomach twice a day, in combination with MTX intramuscular injection as performed in the control group. The treatment efficacy between the two groups were compared. Results The total effective rate of the observation group (92.00%) was significantly higher than that of the control group (72.00%) (P<0.05). Both the time of blood β-HCG level returnning back to normal and the length of hospital stays in the observation group were obviously shorter than those in the control group (P<0.05). Conclusion The combination of MTX and mifepristone is more effective and reliable, safer and easier to be accepted by patients with ectopic gestation, which could be widely used in clinical practice.
KEYWORDS: ectopic gestation; methotrexate; mifepristone
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