不育男性染色体异常和Y 染色体微缺失的相关性研究

陈前

（河南省郑州市天伦医院，河南 郑州，450000）

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摘要：

目的 探究不育男性染色体异常和Y 染色体微缺失的相关性。方法 选取我院2015年1月至2016 年12 月诊治的40例无 精子患者、40 例少精或弱精子患者及40 例健康体检者为研究对象，分别为无精子症组、少弱精子症组和对照组。比较三组染 色体异常情况，同时分析染色体微缺失现象。结果 无精子症组患者的染色体异常率明显高于少弱精子症组及对照组（P<0.05）；少弱精子症组与对照组染色体异常率比较，差异不显著（P>0.05）。无精子症患者中，AZFb、AZFc 及AZFc+AZFb 缺 失的发生率分别为2.5%、5.0%及2.5%，但不同Y 染色体微缺失点位发生率比较，差异不显著（P>0.05）。结论 相比健康男性 与少精或弱精子患者，无精子患者的染色体异常和Y 染色体微缺失情况明显，在辅助技术帮助患者受孕前，建议先进行染色体 异常和Y 染色体微缺失的检测，便于按照其实际情况制定干预方案，降低将染色体异常和Y 染色体微缺失遗传给后代的几率。

关键词：不育男性；染色体异常；Y 染色体微缺失

中图分类号：R698.2文献标志码：A文章编号：2096-1413(2017)32-0136-02

Correlation between chromosome abnormality and Y chromosome microdeletion in infertile men
CHEN Qian
(Tianlun Hospital of Zhengzhou, Zhengzhou 450000, China)

ABSTRACT: Objective To explore the relationship between chromosomal abnormality and Y chromosome microdeletion in infertile men. Methods From January 2015 to December 2016, 40 azoospermia patients were selected as the azoospermia group, 40 patients with oligospermia or asthenospermia were selected as the oligospermia or asthenospermia group, and 40 healthy persons were selected as the control group. The chromosomal abnormality were compared among the three groups, and the Y chromosome microdeletion was analyzed. Results The incidence of chromosomal abnormality in the azoospermia group was significantly higher than that in the oligospermia or asthenospermia group and the control group (P<0.05); there was no significant difference between the oligospermia or asthenospermia group and the control group (P>0.05). In the azoospermia group, the microdeletion rates of AZFb, AZFc and AZFc+AZFb were 2.5%, 5.0% and 2.5% respectively, but there were no significant differences among different Y chromosome microdeletion sites (P>0.05). Conclusion Compared
with healthy male and patients with oligospermia or asthenospermia, azoospermia patients have obvious chromosomal abnormality and Y chromosome microdeletion. The chromosomal abnormality and Y chromosome microdeletion dectections are necessary before patients accepting assistive technology to conceive, so as to make intervention plan according to the actual situation and reduce the rate of the chromosomal abnormality and Y chromosome microdeletion in their offsprings.
KEYWORDS: infertile men; chromosome abnormality; Y chromosome microdeletion

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