小儿抗生素相关性腹泻采用匹多莫德治疗对免疫球蛋白水平及T细胞亚群的影响

屈锐

（西安市长安区医院儿科，陕西 西安，710100）

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摘要：

目的 探究小儿抗生素相关性腹泻采用匹多莫德治疗对免疫球蛋白水平及T 细胞亚群的影响。方法 选择我院2015年 6月至2016年12月收治的72例抗生素相关性腹泻患儿作为研究对象，根据随机数表法将其分为观察组与对照组，每组36 例。对照组进行常规治疗，观察组予以匹多莫德治疗。比较两组治疗效果、免疫球蛋白水平及T 细胞亚群指标变化情况。结果 观察组治疗总有效率高于对照组（P<0.05）。治疗后，两组患者IgA、IgG 水平均明显升高，且观察组显著高于对照组（P<0.05），两组患者的IgM 水平组间、组内比较，差异均不显著（P>0.05）。治疗后，两组患者CD3+、CD4+、CD4+/CD8+水平均明显升高，且 观察组显著高于对照组（P<0.05）；两组患者的CD8+水平组间、组内比较，差异均不显著（P>0.05）。结论 小儿抗生素相关性腹 泻采用匹多莫德治疗能明显提高治疗效果，改善患儿免疫功能，提高机体免疫力，值得临床应用。

关键词：匹多莫德；抗生素相关性腹泻；免疫球蛋白；T 细胞亚群

中图分类号：R442.2文献标志码：A文章编号：2096-1413(2017)34-0103-02

Influence of pidotimod on immunoglobulin level and T cell subsets of antibiotic-associated diarrhea in children
QU Rui
(Pediatrics Department, Chang``an District Hospital of Xi``an, Xi``an 710100, China)

ABSTRACT: Objective To investigate the effect of pidotimod on immunoglobulin level and T cell subsets of antibiotic-associated diarrhea (AAD) in children. Methods A total of 72 cases of children with AAD in our hospital from June 2015 to December 2016 were selected and divided into observation group and control group by random number table, with 36 cases in each group. The control group was given routine treatment, and the observation group was given pidotimod. The curative effects, immunoglobulin levels and changes of T cell subsets indexes were compared between the two groups. Results The total effective rate of the observation group was obviously higher than that of the control group (P<0.05). After treatment, the IgA, IgG levels of the two groups significantly increased, and those in the observation group were significantly higher than the control group (P<0.05); there was no obvious difference in the level of IgM between and in the two groups (P>0.05). After treatment, the CD3+, CD4+, CD4+/CD8+ levels of the two groups significantly increased, and those in the observation group were higher than the control group (P<0.05); there was no obvious difference in the level of CD8+ between and in the two groups (P>0.05). Conclusion Pidotimod in children with AAD can significantly increase curative effects, improve immune function and increase organism immunity, which is worthy of clinical application.
KEYWORDS: pidotimod; antibiotic-associated diarrhea; immunoglobulin; T cell subsets

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