丁螺环酮与氟哌啶醇治疗老年患者全麻术后精神障碍的对比分析

张玉涛，周蕾

（武警陕西总队医院，陕西 西安，710054）

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摘要：

目的 评价丁螺环酮联合氯硝西泮治疗老年患者全麻术后精神障碍（POP）的有效性。方法 随机选取武警陕西总队医院 2010 年1月至2017 年1月全院76 例行全身麻醉术发生POP 的老年患者，按照列表法随机分为试验组（38 例）与对照组（38 例）。试验组患者口服丁螺环酮，对照组患者肌内注射氟哌啶醇，两组患者均于必要时给予氯硝西泮肌内注射。比较两组患者 的Riker 镇静-激越量表（SAS）评分，用药前、后生命体征（包括血压、心率、氧饱和度、呼吸频率等）。结果 所有患者随访2周、1、3 月，未出现复发且无需持续服用抗精神失常药物。治疗后，两组患者的收缩压、舒张压、心率呼吸频率均较治疗前有改善， 且试验组患者上述各项指标优于对照组（P<0.05）。两组患者治疗后的SAS 评分均降低（P<0.05），但两组患者的SAS 评分组 间无显著差异（P>0.05）。结论 丁螺环酮是治疗老年急性POP 安全、有效的药物，值得临床推广应用。
 

关键词：丁螺环酮；术后功能精神障碍（POP）；氟哌啶醇；氯硝西泮

中图分类号：R749.5文献标志码：A文章编号：2096-1413(2017)36-0021-03

Effects comparison of buspirone and haloperidol in elderly patients with postoperative psychonosema after general anesthesia
ZHANG Yu-tao, ZHOU Lei
(Armed Police Corps Hospital of Shaanxi, Xi``an 710054, China)

ABSTRACT: Objective To evaluate the effect of buspirone and haloperi dol in elderly patients with postoperative psychonosema (POP) after general anesthesia. Methods From January 2010 to June 2017, 76 cases of elderly patients with POP in Armed Police Corps Hospital of Shaanxi were randomly selected and divided into experimental group (38 cases) and control group (38 cases) according to the list method. The experimental group was treated with oral buspirone, while the control group was given haloperidol intramuscular injection, both groups were given clonazepam intramuscular when necessary. The riker sedation-exacerbation (SAS) scores, vital signs (including blood pressure, heart rate, oxygen saturation, respiration rate, etc.) before and after treatment were compared between the two groups. Results All patients were followed up for 2 weeks, 1 and 2 months, there was no recurrence and no need to continue taking antipsychotics. After treatment, the systolic blood pressure, diastolic blood pressure, heart rate and respiratory rate in both groups improved compared with those before treatment, and those indexes above in the experimental group were better than the control group (P<0.05). The SAS scores of both groups decreased after treatment (P<0.05), but there was no significant difference in the SAS score between the two groups (P>0.05). Conclusion Buspirone is safe and effective in elderly patients with acute POP, and it is worthy of clinical application.
KEYWORDS: buspirone; postoperative psychonosema (POP); haloperidol; clonazepam

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