药学干预在喹诺酮类药物临床合理应用中的效果分析

王明明，李海涛

（延安大学附属医院，陕西 延安，716000）

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摘要：

目的 探究应用药学干预提升喹诺酮类药物临床合理应用的效果。方法 择取使用喹诺酮类药物治疗的4 000 例患者为研 究对象，按照是否实施药学干预分为对照组和观察组，每组2 000 例。对照组遵循常规医嘱使用喹诺酮类药物治疗，观察组 使用药物前、后均实施药学干预。比较两组用药情况。结果 两组患者使用药物按照频率高低依次为洛美沙星片、左氧氟沙星 片和左氧氟沙星注射液；观察组各类药物利用指数均低于对照组；观察组患者无喹诺酮药物禁忌证用药情况，观察组诺氟沙 星片、加替沙星注射液、洛美沙星片和加替沙星片的超适应证用药情况显著好于对照组（P<0.05）；观察组患者总药物不合理 使用率显著优于对照组（P<0.05）。结论 喹诺酮药物临床应用中实施药学干预，可有效提高临床合理用药水平。

关键词：药学干预；喹诺酮类药物；临床合理用药

中图分类号：R969.3文献标志码：A文章编号：2096-1413(2017)36-0050-02

Effect analysis of pharmaceutical intervention on the rational clinical application of quinolones
WANG Ming-ming, LI Hai-tao
(Yan``an University Affiliated Hospital, Yan忆an 716000, China)

ABSTRACT: Objective To explore the effect of pharmaceutical intervention on the rational clinical application of quinolones. Methods A total of 4 000 patients who used quinolones were selected as the research objects, and divided into observation group and control group according to whether the pharmaceutical intervention was implemented, with 2 000 cases in each group. The control group used the quinolones following the regular doctors`` advice, and the observation group was given pharmaceutical intervention before and after drug use. The situation of medication were compared between the two groups. Results In the two groups, the highest use frequency of quinolones was Lomefloxacin tablets, followed by Levofloxacin tablets and Levofloxacin injection. The drug utilization index of all quinolones in the observation group was lower than those in the control group. In the observation group, there were no use with contraindications of quinolones, and the ultra label use of Norfloxacin tablets, Gatifloxacin injection, Gatifloxacin tablets and Lomefloxacin tablets were significantly better than those in the control group (P<0.05). The total irrational use rate of durg in the observation group was significantly better than that in the control group (P<0.05). Conclusion The implementation of pharmacy intervention for clinical application of quinolones can effectively improve the level of clinical rational use of drugs.
KEYWORDS: pharmaceutical intervention; quinolones; rational clinical drug use

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