甲氨蝶呤、米非司酮联合化瘀消 汤治疗子宫瘢痕妊娠的 临床观察甲氨蝶呤、米非司酮联合化瘀消 汤治疗子宫瘢痕妊娠的临床观察

白云，吴凤琴

（商洛市中心医院，陕西 商洛，726000）

浏览次数：64次 下载次数：360次

摘要：

目的 探讨子宫瘢痕妊娠采用化瘀消癥汤联合甲氨蝶呤、米非司酮治疗的疗效。方法 选取76 例于2015 年3 月至2016 年3 月我院接收的子宫瘢痕妊娠（CSP）患者，随机分为对照组（给予甲氨蝶呤、米非司酮治疗，n=38）与观察组（给予化瘀消癥 汤联合甲氨蝶呤、米非司酮治疗，n=38），观察两组患者的临床疗效。结果 观察组患者的治疗总有效率为86.84%，明显高于对 照组的65.79%（P<0.05）。观察组患者治疗第7、14 天的包块缩小情况均显著优于对照组（P<0.05）。观察组患者的包块消失时 间、血β-HCG 恢复正常时间均短于对照组（P<0.05）。两组患者的不良反应总发生率比较，无显著差异（P>0.05）。结论 化瘀消 癥汤联合甲氨蝶呤、米非司酮治疗子宫瘢痕妊娠，疗效显著，安全性好，具有推广价值。

关键词：子宫瘢痕妊娠；米非司酮；甲氨蝶呤

中图分类号：R714.22 文献标志码：A文章编号：2096-1413(2017)36-0130-02

Clinical observation of methotrexate, mifepristone combined with Huayu Xiaozheng decoction in the treatment

of cesarean scar pregnancy
BAI Yun, WU Feng-qin
(Shangluo Central Hospital, Shangluo 726000, China)

ABSTRACT: Objective To study the therapeutic effect of Huayu Xiaozheng decoction combined with methotrexate and mifepristone on cesarean scar pregnancy. Methods From March 2015 to March 2016, 76 patients with cesarean scar pregnancy (CSP) treated in our hospital were randomly divided into control group (giving western medicine treatment, n=38) and observation group (receiving Huayu Xiaozheng decoction combined with methotrexate, mifepristone treatment, n=38). The therapeutic effects of the two groups were observed. Results The total effective rate of the observation group was 86.84%, which was significantly higher than 65.79% of control group (P<0.05). At 7 and 14 d of treatment, the mass reduction in the observation group were better than those of the control group (P<0.05). The disappearance time of mass, return time of normal blood β-HCG in the observation group were shorter than those of the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Huayu Xiaozheng decoction combined with methotrexate and mifepristone has remarkable effect in the treatment of cesarean
scar pregnancy, with good safety and application value.
KEYWORDS: cesarean scar pregnancy; mifepristone; methotrexate

参考文献：
[1] 彭月享,黄敏,曹辉,等.甲氨蝶呤、米非司酮联合化瘀消癥汤治疗子 宫瘢痕妊娠的临床观察[J].中国药房,2016,27(21):2921-2923.
[2] 戴晓怡,宋建东,刘芳,等.米非司酮联合子宫动脉栓塞术治疗子宫 瘢痕妊娠的疗效观察[J].中国医师进修杂志,2013,36(3):69-71.
[3] 林娟,闫咨儒.甲氨蝶呤介入治疗剖宫产术后子宫瘢痕妊娠的临床 观察[J].中国药房,2016,27(36):5098-5099.
[4] 王静.甲氨蝶呤注射液联合自拟化瘀消癥汤治疗未破损型输卵管 妊娠疗效观察[J].现代中西医结合杂志,2016,25(32):3589-3591.
[5] 李桂春.化瘀消癥汤联合甲氨蝶呤注射液治疗未破损型输卵管妊 娠的效果及起效时间[J].中国疗养医学,2016,25(10):1099-1101.