胺碘酮联合厄贝沙坦治疗心力衰竭合并心律失常的疗效及安全性

刘积伦1，郭亚歌2*

（1.陕西省核工业二一五医院，陕西 咸阳，712000；2.陕西华特玻纤材料集团有限公司职工医院，陕西 咸阳，713100）

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摘要：

目的 分析胺碘酮联合厄贝沙坦治疗心力衰竭合并心律失常的疗效及安全性。方法 将2016 年1 月至2017 年1 月来我院就诊的心力衰竭合并心律失常患者160 例作为研究对象，随机分为观察组及对照组，各80 例。对照组患者给予胺碘酮治疗， 观察组患者给予胺碘酮联合厄贝沙坦治疗。比较两组患者的临床效果、不良反应发生情况及治疗前、后BNP 与Hs-CRP 水 平。结果 观察组患者总有效率为95.00%，明显高于对照组的72.50%（P<0.05）；观察组不良反应总发生率为3.75%，明显低于对照组的12.50%（P<0.05）；治疗后，两组患者的BNP 及Hs-CRP 水平均优于治疗前，且观察组明显优于对照组（P<0.05）。结论 胺碘酮联合厄贝沙坦治疗心力衰竭合并心律失常临床效果显著，不良反应发生率较低。

关键词：胺碘酮；厄贝沙坦；心律失常；心力衰竭

中图分类号：R541.6文献标志码：A文章编号：2096-1413(2018)02-0026-02

Efficacy and safety of amiodarone combined with irbesartan in the treatment of
heart failure complicated with arrhythmia
LIU Ji-lun 1, GUO Ya-ge 2 *
(1. No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang 712000; 2. Worker``s Hospital of Shaanxi Walter Glass Fiber Material Group Co. Ltd, Xianyang 713100, China)

ABSTRACT: Objective To analyze the efficacy and safety of amiodarone combined with irbesartan in the treatment of heart failure complicated with arrhythmia. Methods A total of 160 patients with heart failure complicated with arrhythmia in our hospital were included in the study from January 2016 to January 2017. They were randomly divided into observation group and control group according to the principle of random, with 80 cases in each group. The control group was given amiodarone, and the observation group accepted amiodarone combined with irbesartan. The clinical effects, adverse reactions, BNP and Hs-CRP levels before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 95.00%, which was higher than 72.50% of the control group (P<0.05). The total incidence rate of adverse reactions in the observation group was 3.75%, which was significantly lower than 12.50% in the control group (P<0.05). After treatment, the BNP and Hs-CRP levels of the two groups were better than those before treatment, and those of the observation group were better than the control group (P <0.05). Conclusion Amiodarone combined with irbesartan in the treatment of heart failure complicated with arrhythmia has significant clinical effect and low incidence of adverse reactions.
KEYWORDS: amiodarone; irbesartan; arrhythmia; heart failure

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