氨溴索不同给药方式治疗急性呼吸窘迫综合征的临床观察

王涛1，刘洪波2

（1.陕西省康复医院，陕西 西安，710065；2.西安市中医医院，陕西 西安，710065）

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摘要：

目的 观察氨溴索不同给药方式治疗急性呼吸窘迫综合征的临床效果。方法 选取我院收治的呼吸窘迫综合征患者70 例为研究对象，根据不同治疗方法分为静脉组和序贯组，各35 例。静脉组用静脉滴注法治疗，序贯组用序贯给药法治疗。比 较两组患者治疗前、后动脉PaO2，SaO2，PaO2/FiO2 等血气指标情况，血清中TNF-α、IL-6、IL-10 水平及治疗总有效率。结果 治 疗后，两组患者的PaO2、SaO2、PaO2/FiO2、IL-10 水平均升高，TNF-α、IL-6 均显著降低，且序贯组明显优于静脉组（P<0.05）；序贯组患者治疗总有效率高于静脉组（P<0.05）。结论 盐酸氨溴索治疗呼吸窘迫综合征患者时，序贯给药方式较静脉给药方式 效果更佳。

关键词：盐酸氨溴索；呼吸窘迫综合征；序贯给药

中图分类号：R563.8文献标志码：A文章编号：2096-1413(2018)02-0036-02

Clinical observation of different delivery ways of ambroxol in the treatment of acute respiratory distress syndrome
WANG Tao 1, LIU Hong-bo 2
(1. Shaanxi Kangfu Hospital, Xi``an 710065; 2. Xi``an Hospital of Traditional Chinese Medicine, Xi``an 710065, China)

ABSTRACT: Objective To observe the clinical effects of different delivery ways of ambroxol in the treatment of acute respiratory distress syndrome. Methods Seventy cases of patients with acute respiratory distress syndrome in our hospital were enrolled and divided into venous group (which was treated with intravenous drip, n=35) and sequential group (which was treated with sequential administration, n=35) according to different treatment methods. The arterial PaO2, SaO2, PaO2/ FiO2 and other blood gas indexes before and after treatment, the levels of TNF-α, IL-6 and IL-10 in serum and the total effective rate of treatment were compared between the two groups. Results After treatment, the levels of PaO2, SaO2, PaO2/ FiO2 and IL-10 in the two groups significantly increased, and the levels of TNF-α and IL-6 significantly decreased in the two groups (P<0.05), the levels of those indexes in the sequential group were better than the venous group (P<0.05). The total effective rate of the sequential group was higher than that of the venous group (P<0.05). Conclusion The sequential administration of ambroxol hydrochloride in the treatment of patients with respiratory distress syndrome is better than the intravenous administration.
KEYWORDS: abmroxol hydrochloride; respiratory distress syndrome; sequential administration

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