新生儿呼吸暂停应用纳洛酮联合氨茶碱的疗效分析

田娟1 ，李娟娟1 ，李园2 ，梁宽2*

（1.宝鸡高新人民医院，陕西 宝鸡，721000；2.宝鸡市人民医院，陕西 宝鸡，721000）

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摘要：

目的 观察纳洛酮联合氨茶碱治疗新生儿呼吸暂停的临床疗效。方法 选取2015 年4 月至2017 年4 月在我院出生并确 诊为新生儿呼吸暂停综合征患者70 例为研究对象，随机分为观察组和对照组，各35 例。对照组患儿给予纳洛酮治疗，观察 组患儿在对照组基础上给予氨茶碱治疗，1 个疗程后比较两组患儿呼吸暂停发生次数、持续时间及血氧饱和度、心率、临床 总有效率。结果 治疗后观察组患儿呼吸暂停发生次数较对照组更少，持续时间较对照组明显更短，血氧饱和度、心率均升 高，差异有统计学意义（P<0.05）；治疗后观察组患儿治疗总有效率为88.57%，高于对照组的77.14%（P<0.05）。结论 纳洛酮联 合氨茶碱对新生儿呼吸暂停具有显著疗效。

关键词：纳洛酮；氨茶碱；新生儿呼吸暂停综合征

中图分类号：R72文献标志码：A文章编号：2096-1413(2018)02-0048-02

Curative effect of naloxone combined with aminophylline on neonatal apnea


TIAN Juan 1, LI Juan-juan 1, LI Yuan 2, LIANG Kuan 2 *
(1. the People``s Hospital of Gaoxin District, Baoji 721000; 2. the People``s Hospital of Baoji, Baoji 721000, China)

ABSTRACT：Objective To observe the curative effect of naloxone combined with aminophylline on neonatal apnea. Methods Sixty-eight cases of neonatal apnea treated in our hospital from April 2014 to April 2017 were enrolled as the study objects, and were randomly divided into observation group and control group, with 35 cases in each group. The control group was given naloxone, while the observation group was given aminophylline on the basis of the control group. After a course of treatment, the number and duration of apnea, oxygen saturation, heart rate, and total effective rates were compared between the two groups. Results After treatment, the apnea frequency were less and the apnea duration in the observation group were less lower than those in the control group (P<0.05), and the blood oxygen saturation, heart rate in the observation group were higher than those in the control group (P<0.05); the total effective rate of the observation group was 88.57% , which was higher than 77.14% of the control group (P <0.05). Conclusion Naloxone combined with aminophylline has a significant effect in the treatment of neonatal apnea.
KEYWORDS: naloxone; aminophylline; neonatal apnea syndrome

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