巨噬细胞刺激蛋白在慢性阻塞性肺疾病发病机制中的作用研究

张晓瑜，闫蕊*

（定边县医院内科，陕西 榆林，718600）

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摘要：

目的 分析巨噬细胞刺激蛋白（MSP）在慢性阻塞性肺疾病（COPD）中的作用及相关机制。方法 选取2016 年8 月至2017 年4 月我院收治的COPD 稳定期患者（缓解组）、COPD 急性加重期患者（AECOPD 组）及健康体检者（对照组），各45 例。所有 研究对象均采用酶联免疫吸附法检测血浆MSP 水平；同时，检测AECOPD 组和缓解期组患者诱导痰中的MSP 表达水平。比 较三组的1 s 用力呼出量（FEV1）及用力肺活量（FVC）。结果 AECOPD 组和缓解期组血浆MSP 水平明显高于对照组（P<0.05）；AECOPD 组患者的血浆和诱导痰MSP 水平明显高于缓解期组患者（P<0.05）；AECOPD 组和缓解期组FEV1 及FVC 明显低于 对照组，且AECOPD 组FEV1 及FVC 明显低于缓解期组（P<0.05）。结论 COPD 患者血浆和诱导痰MSP 水平高，且与患者的肺 功能及生活质量密切相关，这可能与MSP 调控巨噬细胞参与气道炎症反应相关。因此，作为可能辅助评估患者肺功能及病 情的指标，COPD 患者血浆和诱导痰MSP 可指导医生进行进一步治疗干预。

关键词：巨噬细胞刺激蛋白（MSP）；慢性阻塞性肺疾病（COPD）；1 s 用力呼出量（FEV1）

中图分类号：R563.9文献标志码：文章编号：2096-1413(2018)02-0088-02

The role of macrophage stimulating protein in the pathogenesis of chronic obstructive pulmonary disease
ZHANG Xiao-yu, YAN Rui *
(Internal Medicine Department, the Hospital of Dingbian County, Yulin 718600, China)

ABSTRACT: Objective To investigate the role of macrophage stimulating protein (MSP) in chronic obstructive pulmonary disease (COPD) and its related mechanism. Methods From August 2016 to April 2017, 45 stable phase COPD patients (stable phase group), 45 acute exacerbation COPD patients (AECOPD group) and 45 healthy physical examiners (control group) were selected as the study objects. All the study objects received plasma MSP detection by enzyme linked immunosorbent assay, and the MSP levels in induced sputum in stable phase group and AECOPD group were detected. The levels of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were compared among the three groups. Results The plasma MSP levels in the stable phase group and AECOPD group were higher than those in the control group (P<0.05); and the plasma MSP and induced sputum MSP levels in the AECOPD group were higher than those in the stable phase group (P<0.05). The levels of FEV1 and FVC in the stable phase group and AECOPD group were lower than those in the control group (P<0.05); and those in the AECOPD group were lower than the stable phase group (P<0.05). Conclusion Plasma and induced sputum MSP levels in COPD patients are associated with the patients`` lung function and life quality, which may be associated with MSP-regulated macrophages involvement in airway inflammation. Thus, as an indicator that may assist in assessing lung function and condition in patients, COPD plasma and induced sputum MSP can further direct physician intervention in its treatment.
KEYWORDS: macrophage stimulating protein (MSP); chronic obstructive pulmonary disease (COPD); forced expiratory volume in 1 s (FEV1)

参考文献：
[1] 王玲玲,赵明静,毛世涛,等.不同分期老年COPD 患者外周血中CD4+、Foxp3+调节性T 细胞变化及其与肺功能改变的相关性[J].中 国老年学,2012,32(2):223-225.
[2] 赵云峰,姜艳平,程改存,等.圣乔治呼吸问卷和慢性阻塞性肺疾病 评估测试问卷评价慢性阻塞性肺疾病稳定期患者健康相关生活 质量的比较[J].上海医学,2013,36(1):47-51.
[3] 苏建,李秀珍.巨噬细胞炎症蛋白-1琢 在慢性阻塞性肺疾病急性加 重期患者血清中的变化[J].实用医学杂志,2013,29(22):3672-3674.
[4] 常嘉琛,焦宗宪.肺泡巨噬细胞及其相关细胞因子与慢性阻塞性肺 疾病相互关系研究进展[J].国际呼吸杂志,2012,32(21):1641-1645.
[5] 王涛,陈小菊,张文波.巨噬细胞刺激蛋白及其受体酪氨酸激酶RON 在慢性阻塞性肺疾病大鼠气道炎症中的作用[J].中国呼吸与危重 监护杂志,2012,11(5):437-443.
[6] 张文波,陈小菊,冷长燕,等.巨噬细胞刺激蛋白在慢性阻塞性肺疾 病患者中的表达及意义[J].中国呼吸与危重监护杂志,2016,15(2):115-118.
[7] 王涛,陈小菊.巨噬细胞刺激蛋白及其受体酪氨酸激酶RON 在慢性阻塞性肺疾病炎性机制中的作用[J].国际呼吸杂志,2013,33(1):37-40.
[8] 杨阳,刘行仁.巨噬细胞刺激蛋白表达水平与慢性阻塞性肺疾病患者肺功能的关系[J].广东医学,2017,38(3):397-401.