7.5%高渗盐水与甘露醇在重症手足口病并发脑水肿患儿中的应用

李刚山

（延安市吴起县人民医院儿科，陕西 延安，717600）

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摘要：

目的 探究分析7.5%高渗盐水与甘露醇在重症手足口病并发脑水肿患儿治疗中的应用效果。方法 回顾性分析我院2012 年4 月至2017 年4 月收治的30 例重症手足口病并发脑水肿患儿的临床资料，将其按照治疗方式分为观察组（n=15）和对照 组（n=15），其中对照组患儿采用甘露醇治疗，观察组患儿采用7.5%高渗盐水与甘露醇治疗，对比观察两组临床治疗效果。结果 治疗前，两组患儿颅内压、平均动脉压以及中心静脉压水平比较，无显著差异（P>0.05）；治疗后，两组患儿上述指标水平均 明显降低，观察组患儿低于对照组（P<0.05）。观察组患儿的临床治疗总有效率（93.33%）明显高于对照组（73.33%）（P<0.05）。结论 重症手足口病并发脑水肿患儿采用甘露醇联合7.5%高渗盐水治疗的临床效果显著。

关键词：高渗盐水；甘露醇；手足口病；脑水肿

中图分类号：R725.1 文献标志码：A文章编号：2096-1413(2018)03-0085-02

Application of 7.5% hypertonic saline and mannitol in children with severe hand-foot-mouth disease complicated

with cerebral edema
LI Gang-shan
(Pediatrics Department, the People``s Hospital of Wuqi County, Yan``an 717600, China)

ABSTRACT: Objective To explore the effect of 7.5% hypertonic saline and mannitol in the treatment of severe hand foot mouth disease complicated with cerebral edema. Methods The clinical data of 30 children with severe hand-foot-mouth disease complicated with cerebral edema admitted in our hospital from April 2012 to April 2017 were restrospectively analyzed, and they were divided into observation group (n=15) and control group (n=15) according to treatmnt methods. The control group was treated with mannitol, while the observation group was treated with 7.5% hypertonic saline and mannitol, the clinical effects between the two group were compared. Results Before treatment, there was no significant difference in the intracranial pressure, mean arterial pressure and central venous pressure between the two groups (P>0.05); after treatment, the levels of above indexs in both groups significantly decreased, those in the observation group were lower than the control group (P<0.05). The total clinical effective rate of the observation group (93.33%) was significantly higher than that of the control group (73.33%) (P<0.05). Conclusion The clinical effect of mannitol combined with 7.5% hypertonic saline is significant in the treatment of children with severe hand-foot-mouth disease complicated with cerebral edema.
KEYWORDS: hypertonic saline; mannitol; hand-foot-mouth disease; cerebral edema

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