经鼻持续正压通气治疗阻塞性睡眠呼吸暂停综合征的临床效果

李日发

（陕西省西乡县人民医院呼吸内科，陕西 汉中，723500）

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摘要：

目的 观察经鼻持续正压通气治疗对阻塞性睡眠呼吸暂停综合征患者的治疗效果及对患者心肌缺血的影响。方法 将78例阻塞性睡眠呼吸暂停综合征患者随机分为两组，对照组患者采用常规药物治疗+面罩吸氧治疗，观察组患者采用常规药物治疗+经鼻持续正压通气治疗。比较两组患者治疗前后睡眠、呼吸紊乱及心肌缺血的改善情况。结果 观察组治疗后睡眠 时间、醒觉时间、呼吸紊乱次数（RDN）、呼吸紊乱指数（RDI）、呼吸暂停次数（OA）、窒息指数（AI）显著优于对照组（P<0.05）；ST段下移发生率显著低于对照组（P<0.05）。两组治疗后心肌缺血总负荷显著低于治疗前，且观察组改善效果更显著（P<0.05）。 结论 采用经鼻持续正压通气治疗阻塞性睡眠呼吸暂停综合征，可显著改善患者睡眠结构，改善呼吸紊乱，也可预防心肌缺血的方式，减轻心肌缺血总负荷。

关键词：持续正压通气；阻塞性睡眠呼吸暂停综合征；心肌缺血

中图分类号：R766文献标志码：A文章编号：2096-1413(2017)05-0010-02

Clinical effect of nasal continuous positive airway pressure on obstructive

sleep  apnea syndrome
LI Ri-fa
(Department of Respiratory Medicine, People's Hospital of Xixiang County, Hanzhong 723500, China)

ABSTRACT: Objective To observe the clinical effect of nasal continuous positive airway pressure on obstructive sleep apnea syndrome and myocardial ischemia. Methods Seventy -eight patients with obstructive sleep apnea syndrome were randomly divided into two groups, the control group was used conventional drug therapy + mask oxygen therapy, while the observation group was used conventional drug treatment and nasal continuous positive airway pressure treatment. The improvement of sleep, breathing disorder and myocardial ischemia in the two groups before and after the treatment were observed. Results The sleep time, awakening time, number of respiratory disorders (RDN), respiratory disturbance index (RDI), number of apnea (OA), asphyxia index (AI) of the observation group after treatment were significantly better than those in the control group (P<0.05); the incidence rate of ST segment depression of the observation group was significantly lower than that in the control group (P<0.05). After treatment, the total load of myocardial ischemia in the two groups was significantly lower than that before treatment, the observation group was more significant (P<0.05). Conclusion In the treatment of obstructive sleep apnea syndrome, nasal continuous positive airway pressure can significantly improve the sleep structure, respiratory distress, and prevent myocardial ischemia, reduce the total burden of myocardial ischemia.

KEYWORDS: continuous positive airway pressure; obstructive sleep apnea syndrome; myocardial ischemia

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