CT引导下穿刺活检表皮生长因子受体表达对肺癌的诊断价值

春增科，林鸣

（宝鸡市第三人民医院，陕西宝鸡，721004）

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摘要：

目的 研究CT引导下穿刺活检表皮生长因子受体表达对肺癌的诊断价值。方法 选取本院2011年6月至2016年6月收治的8例穿刺活检的肺癌患者，根据检查方式将其分为CT组和B超组，各40例。B超组采用PENDAXN EG-3830UT超声仪进行穿刺活检，CT组利用CT扫描机进行定位引导，并基于此选定穿刺体位与穿刺点。比较两组患者穿刺与诊断效果，并分析EGFR表达与并发症发生情况。结果 CT组患者全部实现一次性成功穿刺(100.0%)，而B超组一次性穿刺仅为32例(80.0%)，二次穿刺5例(12.5%)，三次穿刺3例(7.5%);在CT组患者的诊断中有36例被成功诊断为肺癌，而B超组仅有32例被成功诊断为肺癌;在CT组患者的诊断中EGFR 的阳性表达准确率高达95.0%，而B超组的阳性表达准确率仅为82.5%。而诊断的过程中CT组患者出现并发症的患者少于B超组。结论 CT引导下穿刺活检表皮生长因子受体表达对肺癌的诊断具有显著临床意义。

关键词：CT引导；肺癌诊断；表皮生长因子

中图分类号：R734.2文献标志码：A文章编号：2096-1413(2017)05-0136-02

The diagnostic value of CT-guided puncture biopsy of the expressione of pidermal growth factor receptor on lung cance

CHUN Zeng-ke, LIN Ming

(the Third People's Hospital of Baoji, Baoji 721004, China)

ABSTRACT: Objective To explore the value of CT-guided puncture biopsy of the expression of epidermal growth factor receptor in the diagnosis of lung cancer. Methods Eighty cases of lung cancer patient underwent needle biopsy in our hospital from June 2011 to June 2016 were selected and divided into type-B ultrasonic group and CT group, with 40 cases in each group. type-B ultrasonic group performed biopsy centesis with PENDAXN EG-3830UT ultrasound, while CT group chose puncture position and puncture point based on CT scanner for positioning and guiding, then the puncture and diagnosis effect were compared between the two groups, and epidermal group foutor expression and incidence of complications were analyzed. Results All the patients of CT group achieved a one-time successful puncture (100.0%), and type-B group ultrasonic achieved 32 patients (80%) with one-time puncture, 5 patients (12.5%) with two-time puncture, 3 cases (7.5%) with three-time puncture. 36 patients of CT group were diagnosed with lung caner, and 32 patients in Group type-B ultrasonic were diagnosed with lung cancer. The positive rate of epidermal growth factor expression in CT group was 95.0%, and that in type-B group ultrasonic was 82.5%. The incidence of complications in CT group was fewer than that in type-B group ultrasonic. Conclusion CT-guided percutaneous biopsy for detecting the expression of epidermal growth factor receptor of in the diagnosis of lung cancer has significant promoting value.

KEYWORDS: CT-guided; diagnosis of lung cancer; epidermal growth factor

参考文献：

[1] 左敬全,史永惠.CT 引导下穿刺活检表皮生长因子受体表达对于肺癌诊断的价值[J].实用癌症杂志,2015,30(8):1184-1186.

[2] 王海彦,庄一平,张晋,等.CT引导下经皮细针穿刺活检检测中晚期肺癌表皮生长因子受体基因突变[J].中国介入影像与治疗学,2013,10(1):33-36.

[3] 徐维,邓博,吴跃锐,等.CT引导下非小细胞肺癌穿刺标本检测表皮生长因子受体基因突变的临床应用[J].北方药学,2014,11(6):75-76.

[4] 张鸿文,张芨,雷娟,等.CT引导下经皮肺穿刺活检在管外型中央型肺癌中的诊断价值[J].临床肺科杂志,2012,17(5):886-888.

[5] CHEUNG YC,CHANG WC,HSIEH JJ,et al.Adequacy and complica-tions of computed tomography-guided core needle biopsy on non-small cell lung cancers for epidermal growth factor receptor mutations demon-stration: 18-gauge or 20-gauge biopsy needle[J].Lung Cancer,2010,67(2):166-169.

[6] 高正兴,童朝晖.早期肺癌患者主气道上皮细胞表皮生长因子受体mRNA表达的初步探讨[J].中国肿瘤临床与康复,2015,22(2):129-132.

[7] 侯晓玮,庄兴俊,宋谦,等.CT引导经皮肺穿刺活检检测晚期非小细胞肺癌表皮生长因子受体基因突变[J].介入放射学杂志,2013,22(2):125-128.