子宫肌瘤应用不同剂量米非司酮治疗的疗效观察

苏晓玲

（陕西省岐山县医院，陕西宝鸡，722400）

浏览次数：80次 下载次数：292次

摘要：

目的 观察子宫肌瘤应用不同剂量米非司酮治疗的效果。方法 收集我院妇产科2013年1月至2015年12月收治的子宫肌瘤患者110例作为研究对象，随机分为观察组和对照组，每组患者55例。观察组应用低剂量米非司酮治疗（12.5 mg/d），对照组应用常规剂量米非司酮治疗（25.0 mg/d），分别观察两组患者治疗3、6个月的疗效，比较两组患者近、远期疗效。结果 两组患者经3个月治疗后，两组治疗总有效率均为76.36%，观察组治疗6个月的总有效率为89.09%，而对照组为87.27%，两组患者同期治疗效果比较无明显差异，但组内治疗6个月和治疗3个月比较有显著差异（P<0.05）。两种药物治疗后瘤体积较治疗前均显著减小（P<0.05）。观察组的不良反应发生率（7.00%）低于对照组（21.80%），差异有统计学意义（P<0.05）。结论 12.5mg/d米非司酮治疗子宫肌瘤可达到常规剂量治疗疗效，且不良反应较常规剂量少，可在临床推广应用。

关键词：子宫肌瘤；米非司酮；低剂量

中图分类号：R737.33文献标志码：A文章编号：2096-1413(2017)07-0086-02

Curative effect of different doses of mifepristone in the treatment of uterine myoma

SU Xiao-ling

(Qishan County Hospital, Baoji 722400, China)

ABSTRACT: Objective To observe the curative effect of different doses of mifepristone in the treatment of uterine myoma. Methods One hundred and ten patients of uterine myoma from January 2013 to December 2015 were randomly divided into observation group and control group, 55 cases in each group. The observation group received low dose mifepristone treatment (12.5 mg/d); the control group was treated with routine dose of mifepristone treatment (25.0 mg/d). The curative effect of two groups of patients were observed in 3 months and 6 months respectively, and the short-term and long-term effects of the two groups were compared. Results The total effective rate of the two groups after 3 months was 76.36%, the total effective rate of observation group after 6 months was 89.09%, while the control group was 87.27%, the difference between the two groups was not significant at the same phase (P>0.05), but the differences between the curative rate of 3 months and 6 months was significant (P<0.05). The tumor volume after treatment of two groups were smaller than before, the difference were significant (P>0.05). The adverse reaction rate of the observation group (7.00%) was less than 21.8% of the control group (P<0.05). Conclusion 12.5 mg /d mifepristone is not only effective as conventional dose, but also safe, which is worthy clinical application.

KEYWORDS: uterine myoma; mifepristone; low dose

参考文献：
[1] 乔海英.不同剂量米非司酮治疗子宫肌瘤的疗效观察及安全性分析[J].临床医学,2014,39(12):110-111.
[2] 魏崇丽.子宫肌瘤患者应用不同剂量米非司酮的临床效果观察[J].药物与人,2014,4(5):96-96.
[3] 孙颖莉.不同剂量米非司酮治疗子宫肌瘤的效果观察[J].大家健康:学术版,2014,24(23):138-139.
[4] 路彩侠.两种不同剂量米非司酮治疗子宫肌瘤的疗效观察[J].中国医药指南,2013,11(32):152-153.
[5] 邵会敏,王彩芳,彭宇,等.45例子宫肌瘤患者应用米非司酮治疗的临床观察[J].现代诊断与治疗,2015,26(8):1771-1772.
[6] 彭松玉,张天会.血府逐瘀汤联合米非司酮治疗子宫肌瘤临床疗效观察[J].现代中西医结合杂志,2014,23(14):1530-1532.
[7] 余霞,袁晓燕,犹力.不同剂量米非司酮在子宫肌瘤保守治疗中的疗效分析[J].西部医学,2014,26(5):639-640.