介入联合无水酒精注射治疗直肠癌伴肝转移疗效及安全性评价

延生斌

（陕西省榆林市绥德县医院综合外科，陕西榆林，718000）

浏览次数：160次 下载次数：400次

摘要：

目的 探讨直肠癌伴肝转移采用不同方法治疗的安全性和疗效。方法 选择我院收治的80例直肠癌伴肝转移患者，随机分为观察组和对照组，每组40例；对照组患者实施直肠癌根治手术治疗，观察组患者实施介入联合无水酒精注射术。比较两组患者治疗方法的临床疗效。结果 观察组患者的治愈、显效、总有效率高于对照组，无效、复发率低于对照组（P<0.05），但两组的死亡率比较无明显差异（P>0.05）；观察组患者的感染率、不良反应总发生率低于对照组（P<0.05），而两组的血管堵塞、肿胀、肝功能不全及胸腔积液发生率比较无明显差异（P>0.05）。结论 在治疗直肠癌伴肝转移中，两种治疗方法均有效，但介入联合无水酒精注射术治疗安全性更高，不良反应较少，值得临床医师广泛应用。

关键词：直肠癌伴肝转移；介入联合无水酒精注射术；安全性

中图分类号：R735.3文献标志码：A文章编号：2096-1413(2017)09-0044-02

Efficacy and safety of intervention combined with absolute alcohol injection on hepatic metastasis from colorectal cancer

YAN Sheng-bin

(Department of General Surgery, Suide County Hospital, Yulin 718000, China)

ABSTRACT: Objective To investigate the efficacy and safety of different methods in the treatment of hepatic metastasis from colorectal cancer. Methods Eighty cases of patients with hepatic metastasis from colorectal cancer in our hospital were selected and randomly divided into observation group and control group, with 40 cases in each group. The control group im-plemented rectal carcinoma radical operation, the observation group received intervention combined with absolute alcohol injection. The clinical effect between the two groups was compared. Results The cure rate, significant rate and total effective rate in the observation group were higher than those of the control group, the inefficiency, recurrence rate were lower than those of the control group (P约0.05), but there was no significant difference in death rate of the two groups (P>0.05). The infection rate, total incidence rate of adverse reactions in the observation group were lower than those of the control group,but there was no significant difference in the blood vessel, swelling, hepatic insufficiency and pleural effusion of the two groups (P>0.05). Conclusion The two kinds of treatment methods are all effective in the treatment of patients with hepatic metastasis from colorectal cancer, but the intervention combined with absolute alcohol injection has higher safety, less adverse reaction, it is worthy of widely application in clinic.

KEYWORDS: hepatic metastasis from colorectal cancer; intervention combined with absolute alcohol injection; safety

参考文献：
[1] 陈文政.结直肠癌肝转移个体化综合性治疗的研究进展[J].大连医科大学学报,2016,38(1):97-100,102.
[2] 陈红卫.晚期结直肠癌肝转移临床介入治疗体会[J].中国卫生标准管理,2016,7(10),26-27.
[3] 简乾洪,郑方荣,阎雄.经肝动脉化疗栓塞术治疗结直肠癌肝转移的研究进展[J].临床肝胆病杂志,2016,32(6):1216-1219.
[4] 中华医学会外科学分会胃肠外科学组.结直肠癌肝转移诊断和综合治疗指南[J].中国实用外科杂志,2016,15(8):755-764.
[5] 杨甲梅,施长鹰.结直肠癌肝转移手术治疗再探讨[J].中国实用外科杂志,2016,36(4):374-378.
[6] 邵赏,李慧杰,齐元富.结直肠癌肝转移的中西医治疗进展[J].山东中医杂志,2016,35(1):86-88.
[7] 郑民华,马君俊.结直肠癌肝转移的腹腔镜微创手术治疗[J].中华胃肠外科杂志,2015,18(6):521-524.
[8] 冷家骅,武爱文.结直肠癌肝转移的E-SPLIT系统性评价方法及其意义[J].中国实用外科杂志,2016,36(4):387-391.