喜炎平与利巴韦林治疗小儿手足口病的效果及安全性

吉朝利，杨学武，曹珍珍，马宁

（陕西省榆林市第二医院儿科，陕西榆林，719000）

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摘要：

目的 分析喜炎平联合利巴韦林治疗手足口病的临床应用效果。方法 选择2011年1月至2015年12月我院收治的手足口病患儿308例为研究对象，随机分为对照组和治疗组，每组154例。对照组患儿接受利巴韦林治疗；治疗组患儿采用利巴韦林联合喜炎平进行治疗。比较两组患儿的临床疗效、体温复常时间、疱疹和皮疹消退时间、药物干预治疗时间及不良反应发生情况。结果 治疗组患儿的临床疗效明显优于对照组，差异具有统计学意义（P<0.05）；治疗组患儿体温复常时间、疱疹和皮疹消退时间及药物干预治疗时间明显短于对照组，差异具有统计学意义（P<0.05）；治疗组患儿不良反应发生率明显低于对照组，差异具有统计学意义（P<0.05）。结论 应用利巴韦林联合喜炎平治疗小儿手足口病效果显著，值得临床推广。

关键词：手足口病；利巴韦林；喜炎平

中图分类号：R725.1文献标志码：A文章编号：2096-1413(2017)09-0066-02

Effect and safety of Xiyanping and ribavirin on pediatric hand, foot and mouth disease

JI Zhao-li, YANG Xue-wu, CAO Zhen-zhen, Ma Ning

(Department of Pediatrics, the Second Hospital of Yulin, Yulin 719000, China)

ABSTRACT: Objective To analyze the clinical effect of Xiyanping and ribavirin on pediatric hand, foot and mouth disease. Methods Three hundred and thirty eight cases of children with hand, foot and mouth disease admitted in our hospital from January 2011 to December 2015 were selected as the study objects. All the children were randomly divided into control group and treatment group, with 154 cases in each group. The control group received ribavirin, while the treatment group accepted Xiyanping combined with ribavirin. The clinical effect, temperature recovery time, herpes and rash regression time, drug intervention time and the incidence of adverse reactions of the two groups were compared. Results The clinical effect of the treatment group was better than that of the control group, the difference was statistically significant (P<0.05). The temperature recovery time, herpes and rash regression time and drug intervention time of the treatment group were shorter than those of the control group, the differences were statistically significant (P<0.05). The incidence rate of the adverse reactions was lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion Xiyanping combined with ribavirin in the treatment of pediatric hand, foot and mouth disease has significant clinical effect, which is worthy of clinical application and popularization.

KEYWORDS: hand, foot and mouth disease; ribavirin; Xiyanping

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