气管镜联合氨溴索雾化吸入治疗卒中相关性肺炎的临床分析

刘鸿儒

（首都医科大学附属北京友谊医院平谷医院，北京，101200）

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摘要：

目的 分析对卒中相关性肺炎患者实施气管镜联合氨溴索治疗的临床效果。方法 选取76例卒中相关性肺炎患者开展临床试验，随机将其分为联合组和常规组，各38例。常规组实施祛痰、抗感染等常规支持治疗，联合组在此基础上另实施气管镜联合氨溴索雾化吸入治疗，对比两组患者的临床疗效，治疗前、后白细胞和C-反应蛋白（CRP）水平变化情况。结果 两组患者的临床疗效分布和总有效率比较，差异有统计学意义（P<0.05）；治疗前，两组的白细胞、CRP水平比较，差异均无统计学 意义（P>0.05）；治疗后，两组白细胞、CRP水平均显著降低（P<0.05），且联合组低于常规组（P>0.05）；联合组不良反应总发生 率为5.26%，稍高于常规组的0.00%，但差异没有统计学意义（P>0.05）。结论 在卒中相关性肺炎患者治疗中采用气管镜联合氨溴索，能显著改善疗效，减轻炎症反应，且并不会显著增加不良反应。

关键词：气管镜；氨溴索；卒中相关性肺炎；炎症反应

中图分类号：R563.1文献标志码：A文章编号：2096-1413(2017)12-0017-02

Clinical analysis of bronchoscopy combined with ambroxol in the treatment of patients with stroke associated pneumonia
LIU Hong-ru
(Pinggu Hospital Affiliated to Beijing Youyi Hospital, Capital Medical University, Beijing 101200, China)

ABSTRACT: Objective To analyze the clinical effect of bronchoscopy combined with ambroxol in the treatment of patients with stroke associated pneumonia. Methods Seventy-six cases of patients with stroke associated pneumonia were selected into the clinical experiment and divided into combination group and routine group, with 38 cases in each group. The routine group received routine supportive treatment as expectorant and anti infection, while the combination group was given bronchoscopy combined with ambroxol inhalation therapy. The clinical efficacy and changes of levels of leukocyte and C- reactive protein (CRP) before and after treatment were compared. Results There were significant differences in the distribution of clinical efficacy and total effective rates between the combination group and the routine group (P<0.05). There were no significant differences in the levels of leukocyte and CRP before treatment between the two groups (P<0.05), which were significantly decreased after treatment (P<0.05), and the levels in the combination group were significantly lower than those of the routine group (P<0.05). The total incidence rate of adverse reactions in the combination group was 5.26% , which was slightly higher than 0.00% in the routine grou, but there was no significant difference (P >0.05).Conclusion The application of bronchoscopy combined with ambroxol in the treatment of stroke associated pneumonia can significantly improve the efficacy and reduce inflammation, while does not significantly increase adverse reactions.

KEYWORDS: bronchoscopy; ambroxol; stroke associated pneumonia; inflammation

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