雷贝拉唑联合克拉霉素及甲硝唑治疗浅表性胃炎的疗效及机制研究

邱爱龙

（陕西省渭南市华县中铁一局集团中心医院消化内科，陕西 渭南，714100）

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摘要：

目的 分析雷贝拉唑联合克拉霉素及甲硝唑治疗浅表性胃炎的临床疗效及机制。方法 选取我院收治的100例浅表性胃炎患者作为研究对象，将所有患者按照随机数字表法分为两组，各50例。对照组采用克拉霉素联合甲硝唑治疗，观察组在对照组治疗的基础上加用雷贝拉唑，对比两组临床疗效，治疗前、后的炎症因子及超氧化物歧化酶（SOD）及丙二醛（MDA）水 平。结果 观察组治疗总有效率为94.00%，对照组患者为70.00%，两组比较，差异有统计学意义（P<0.05）。治疗后，两组患者炎症因子及SOD、MDA水平均有所改善（P<0.05），且观察组患者IL-2、SOD水平均高于对照组，IL-4、IL-8及MDA水平低于对照组（P<0.05）。结论 雷贝拉唑联合克拉霉素及甲硝唑在治疗浅表性胃炎中具有较好的临床疗效，在缓解患者临床症状的 同时能改善患者炎症因子水平，对胃黏膜的恢复具有重要作用，在临床应用中值得推广。

关键词：雷贝拉唑；克拉霉素；甲硝唑；浅表性胃炎

中图分类号：R573.1 文献标志码：A文章编号：2096-1413(2017)13-0048-02

Efficacy and mechanism of rabeprazole combined with clarithromycin and metronidazole on superficial gastritis
QIU Ai-long
(Department of Gastroenterology, Centre Hospital of Hua County China Railway First Group Co. , Weinan 714100, China)

ABSTRACT: Objective To analyze the clinical efficacy and mechanism of rabeprazole combined with clarithromycin and metronidazole in patient with superficial gastritis. Methods One hundred cases of patients with superficial gastritis in our hospital were divided into two groups with random number table, with 50 cases in each group. The control group took rabeprazole combined with clarithromycin, the observation group added metronidazole on the basis of the control group. The clinical efficacy, inflammatory factor, SOD and MDA levels before and after treatment of two groups were compared. Results The total curative effective rate of the observation group was 94.00%, which was higher than 70.00% of the control group (P<0.05). After treatment, the inflammatory factor and SOD and MDA levels improved in the two groups, and IL-2,SOD levels of the observation group were higher than those of the control group, the IL-4, IL-8 and MDA levels were lower than those of the control group (P<0.05). Conclusion Rabeprazole combined with clarithromycin and metronidazole in patient with superficial gastritis has better clinical efficacy, it can relieve clinical symptoms, improve levels of inflammatory factors and facilitate recovery of gastric mucosa, which is worthy of clinical promotion.
KEYWORDS: rabeprazole; clarithromycin; metronidazole; superficial gastritis

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