炎琥宁与利巴韦林治疗婴幼儿秋季腹泻的疗效和安全性比较

张慧萍

（陕西省渭南市华县中铁一局集团中心医院儿科，陕西 渭南，714100）

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摘要：

目的 比较炎琥宁与利巴韦林治疗婴幼儿秋季腹泻的疗效和安全性。方法 选取我院收治的秋季腹泻患儿86例，根据随机数表法将所有患儿分为对照组和观察组，各43例。两组均给予补液、纠酸、抗感染等辅助治疗，对照组应用利巴韦林治疗，观察组给予炎琥宁治疗。对两组临床疗效、临床症状缓解时间及不良反应展开对比分析。结果 观察组临床治疗总有效率 明显高于对照组（P<0.05）；观察组止泻时间、粪便性状改善时间、退热时间均明显短于对照组（P<0.05）；两组患儿均未出现肝肾功能损伤、白细胞异常等不良反应。结论 炎琥宁治疗婴幼儿秋季腹泻，安全高效，相比于利巴韦林，能够明显加快患儿康复进程，减少大便次数，改善粪便性状，纠正脱水，消除症状，值得推广应用。

关键词：婴幼儿秋季腹泻；炎琥宁；利巴韦林

中图分类号：R725.1文献标志码：A文章编号：2096-1413(2017)13-0046-02

Efficacy and safety comparison of andrographolide and ribavirin in the treatment of infantile autumn diarrhea
ZHANG Hui-ping
(Department of Pediatrics, Hua County Railway Group Central Hospital, Weinan 714100, China)

ABSTRACT: Objective To compare the efficacy and safety of andrographolide and ribavirin in the treatment of infantile autumn diarrhea. Methods Eighty-six cases of infantile autumn diarrhea in our hospital were divided into control group and observation group according to random number table, with 43 cases in each group. The two groups were given adjuvant treatment with fluid infusion, correcting acid, anti -infection. The control group took ribavirin and the observation group took andrographolide. The clinical efficacy, remission duration of clinical symptoms and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). The antidiarrheal time, fecal character improvement time and fever clearance time of the observation group were significantly shorter than those of the control group (P<0.05). There were no liver-kidney damage, leukocyte disorder and other adverse reaction in the two groups. Conclusion Andrographolide is safe and efficient in treating infantile autumn diarrhea, compared with ribavirin, it can obviously accelerate recovery, reduce defection frequency, improve fecal character, correct dehydration and eliminate symptoms, which is worthy of application.
KEYWORDS：infantile autumn diarrhea; andrographolide; ribavirin

参考文献：
[1] 邢滔.参苓白术散合戊己丸加减治疗小儿秋季腹泻64例疗效观察[J].浙江中医药大学学报,2014,38(6):744-745.
[2] 冯娜.中西医结合治疗小儿病毒性腹泻的疗效观察[J].陕西中医,2015,36(10):1365.
[3] 全国腹泻病防治学术研讨会.中国腹泻病诊断治疗方案[J].中国实用儿科杂志,1998,13(6):381-384.
[4] 方鹤松,魏承毓,段恕诚,等.腹泻病疗效判断标准的补充建议[J].中国实用儿科杂志,1998,13(6):381-384.
[5] 廖春周.炎琥宁治疗婴幼儿秋季腹泻120例疗效观察[J].中国医药导刊,2013,15(12):2038-2039.
[6] 郝艳玲.应用妈咪爱与蒙脱石散治疗小儿腹泻的临床疗效观察[J]. 临床医学研究与实践,2016,1(18):46-47.
[7] 薛继红.热毒宁注射液联合利巴韦林治疗小儿病毒性肠炎50例 [J].中国药业,2015,24(18):124-126.
[8] 齐纪芳.炎琥宁治疗婴幼儿秋季腹泻46例的疗效观察[J].现代消化及介入诊疗,2016,21(2):346-347.
[9] 张文亮,饶雪梅,罗兰芳.炎琥宁注射液配合西医常规疗法治疗小儿轮状病毒肠炎临床研究[J].国际中医中药杂志,2016,38(9):814-816.

[10] 刘红.炎琥宁联合消旋卡多曲颗粒治疗婴幼儿急性腹泻的效果 [J].中国医药导报,2015,12(26):126-129.