小儿热性惊厥转为癫痫高危因素分析

杨慧，吴莹，朱航

（陕西省核工业二一五医院儿科，陕西 咸阳，712000）

浏览次数：117次 下载次数：280次

摘要：

目的 研究热性惊厥患儿发展为癫痫的危险因素。方法 收集2008年1月至2012年12月在我科住院的首次发作热性惊厥（FC）患儿258例进行随访，结合患儿临床资料及脑电图、头颅影像学资料，研究其转为癫痫的危险因素。结果 热性惊厥转为癫痫共51例（19.7%），转为癫痫的危险因素与首次FC发作年龄<12 个月、有癫痫家族史、复杂型FC、惊厥前热程≤1 h、FC发作1周后EEG异常、围产期异常、头颅影像学异常、有神经系统发育异常（脑瘫、脑积水）等相关，危险因素越多，转变成 癫痫的风险越大。结论 热性惊厥患儿绝大部分预后较好，对有转为癫痫危险因素的患儿，应密切随访，采取适当的干预措施。

关键词：热性惊厥；癫痫；危险因素

中图分类号：R742.1文献标志码：A文章编号：2096-1413(2016)25-0016-02

Analysis of high risk factors in children with febrile convulsion converting to epilepsy
YANG Hui, WU Ying, ZHU Hang
(Department of Pediatric, No. 215 Hospital of Shaanxi Nuclear Industry, Xianyang 712000, China)

ABSTRACT: Objective To investigate the risk factors in children with febrile convulsion converting to epilepsy. Methods Two hundred and fifty-eight cases of children with febrile convulsion (FC) were collected from January 2008 to December 2012 in our department, and their clinical data and electroencephalogram (EEG), brain imaging data were analyzed to study the risk factors of it converting to epilepsy. Results There were 51 cases (19.7%) converted to epilepsy. The risk factors of epilepsy were first febrile convulsion age less than 12 months, epilepsy family history, complex type FC, febrile convulsion time for less than or equal to 1 h, abnormal EEG at 1 week after FC, perinatal abnormalities, abnormal head imaging, developmental abnormalities of the nervous system (cerebral palsy, hydrocephalus). The more risk factors were, the higher the risk of converting into epilepsy was. Conclusion Most of the children with FC have a good prognosis. However, the children who have the risk factors of epilepsy should be followed up closely and take appropriate intervention measures.
KEYWORDS: febrile convulsions; epilepsy; risk factors

参考文献：
[1] CAPOVILLA G,MASTRANGELO M,ROMEO A,et al.Recommendations for the management of "febrile seizures"：Ad Hoc Task Force of
LICE Guidelines Commission[J].Epilepsia,2009,50(Suppl 1):2-6.
[2] PAUL SP,BLAIKLEY S,CHINTHAPALLI R,et al.Clinical update: febrileconvulsion in childhood[J].Community Pract,2012,85(7):36-38.
[3] LIN Y,ITOMI K,TAKADA H,et al.Benign myoclonic epilepsy in infants: video-EEG features and long-term follow-up[J].Neuropediatrics, 1998,29(5):268-271.
[4] 左启华.小儿神经系统疾病[M].北京:人民卫生出版社,2002:56.
[5] 王兰英.探讨防治小儿热性惊厥与癫痫分析[J].特别健康:下,2014,12(7):41.
[6] 周东,汪颖,吴逊.国际抗癫痫联盟委员会关于癫痫发作和癫痫诊 断方案的建议[J].中华神经科杂志,2003,32(4):302-307.
[7] 张邵军.小儿复杂型热性惊厥临床研究[J].中国实用医刊,2012,39(18):58-59.
[8] 丁昌红.热性惊厥的流行病学特点、病因及发病机制[J].中国社区 医师,2010,13(15):5.
[9] 潘子琴.小儿热性惊厥的临床治疗进展[J].中国医药指南,2013,33(21):450-451.
[10] 董红溪.小儿热性惊厥复发相关因素的临床探析[J].中外医疗,2013,33(33):70-71.