雷替曲塞化疗联合放疗治疗局部晚期直肠癌的效果观察

王亚儒

（陕西省宝鸡市中心医院肛肠外科，陕西 宝鸡，721008）

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摘要：

目的 探讨雷替曲塞化疗联合放疗对局部晚期直肠癌患者的治疗效果及毒副作用。方法 选取我院2014年5月至 2016年5月收治的局部晚期直肠癌患者80例，依据治疗方法将患者分为雷替曲塞化疗联合放疗组（雷替曲塞组，n=40） 和5-氟尿嘧啶化疗联合放疗组（5-氟尿嘧啶组，n=40），对两组患者的临床疗效、毒副反应发生情况进行比较分析。结果 雷替曲塞组患者的临床总缓解率为60.0%（24/40），明显高于5-氟尿嘧啶组的27.5%（11/40）（P<0.05）。雷替曲塞组患者的Ⅰ～Ⅱ级恶心呕吐、转氨酶升高发生率均明显低于5-氟尿嘧啶组（P<0.05）；但两组患者的Ⅰ～Ⅱ级白细胞下降、周围神经炎、放射性膀胱炎、放射性直肠炎发生率之间的差异均无统计学意义（P>0.05）；Ⅲ～Ⅳ级恶心呕吐、白细胞下降、转氨酶升高、周围神经炎、放射性膀胱炎、放射性直肠炎发生率之间的差异均不显著（P>0.05）。结论 雷替曲塞较5-氟尿嘧啶化疗联合放疗能更有效地提升局部晚期直肠癌患者的治疗效果，减轻毒副作用，从而有效改善患者预后，值得推广。

关键词：雷替曲塞化疗联合放疗；局部晚期直肠癌；毒副作用；预后

中图分类号：R735.37文献标志码：A文章编号：2096-1413(2017)18-0014-03

Effect observation of raltitrexed chemotherapy combined with radiotherapy in the treatment of localized advanced colorectal cancer
WANG Ya-ru
(Department of Colorectal Surgery, Baoji Central Hospital, Baoji 721008, China)

ABSTRACT: Objective To investigate the effect of raltitrexed chemotherapy combined with radiotherapy on the therapeutic effect and side effects of patients with locally advanced rectal cancer. Methods Eighty cases of patients with locally advanced rectal cancer admitted in our hospital from May 2014 to May 2016 were selected, all the patients were divided into raltitrexed chemotherapy combined with radiotherapy group (raltitrexed group, n=40) and 5-fluorouracil chemotherapy combined with radiotherapy group (5-fluorouracil group, n=40) according to the treatment methods. The clinical curative effects and incidence of adverse reactions of the two groups were statistically compared and analyzed. Results The total remission rate of raltitrexed group was 60.0% (24/40), which was higher than 27.5% (11/40) of the 5-fluorouracil group (P<0.05). In raltitrexed group, the incidence of gradeⅠ～Ⅱ nausea, vomiting and transaminase increasing were lower than those in the 5-fluorouracil group (P<0.05), but the differences on incidence rates of gradeⅠ～Ⅱwhite blood cells decreasing, peripheral neuritis, radiation cystitis and radiation proctitis were not significant (P>0.05); there was no significant difference on the incidence of Ⅲ～Ⅳ nausea and vomiting, leukopenia, elevated transaminase, peripheral neuritis, radioactive cystitis and radiation proctitis between the two groups (P>0.05). Conclusion Compared with 5-fluorouracil chemotherapy combined with radiotherapy, raltitrexed chemotherapy combined with radiotherapy can largely enhance the treatment effect of patients with locally advanced rectal cancer, reduce side effects, thus effectively improves the prognosis of the patients, which is worth promoting.
KEYWORDS: raltitrexed chemotherapy combined with radiotherapy; locally advanced rectal cancer; side effects; prognosis

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