依达拉奉联合银杏二帖内酯葡胺注射液治疗急性脑梗死的疗效观察

李守林1 ，周伟1 ，朱小浩1 ，许锁1 ，李娟2，武敏1

（连云港市第一人民医院：1.急诊观察病区；2.神经内科，江苏 连云港，222002）

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摘要：

目的 观察依达拉奉联合银杏二帖内酯葡胺注射液（GTLMI）治疗急性脑梗死的疗效及安全性。方法 收集我院收治的 70例急性脑梗死患者的临床资料，根据不同治疗方法分为常规治疗组（35例）和观察组（35例）。常规治疗组患者给予依达拉奉和常规基础治疗；观察组患者在此基础上联合GTLMI 治疗。疗程均为14 d。观察对比两组患者治疗前、后神经功能缺损评分变化情况及临床疗效。结果 治疗前，两组患者的神经功能缺损评分比较，差异不显著（P>0.05）；治疗后，两组的神经功能缺损评分均显著降低（P<0.05），且观察组的神经功能缺损评分低于常规治疗组（P<0.05）。观察组总有效率为88.57%，高于常规 治疗组的71.43%（P<0.05）。两组均无死亡病例。结论 依达拉奉联合GTLMI治疗急性脑梗死安全有效，值得临床推广应用。

关键词：银杏二萜内酯葡胺注射液；依达拉奉；急性脑梗死；神经功能缺损评分

中图分类号：R743.3 文献标志码：A文章编号：2096-1413(2017)18-0035-02

Efficacy observation of edaravone combined with ginkgo terpene lactones meglumine injection in the treatment of acute cerebral infarction
LI Shou-lin 1, Zhou Wei 1, ZHU Xiao-hao 1, XU Suo 1, LI Juan 2, Wu min 1
(1. Emergency Observation Ward; 2. Department of Neurology, the First People``s Hospital of Lianyungang, Lianyungang 222002, China)

ABSTRACT: Objective To observe the efficacy and safety of combination between edaravone and ginkgo terpene lactones meglumine injection (GTLMI) on acute cerebral infarction. Methods Seventy cases of acute cerebral infarction patients admitted in our hospital were randomly divided into conventional group (35 cases) and observation group (35 cases). The conventional group received edaravone and conventional basic therapy, while the observation group combined with GTLMI on the basis of the conventional group. Treatment time was 14 days. The neurological deficit scores and efficacy before and after treatment of the two groups were compared. Results Before treatment, the difference of neurological deficit scores between the two groups was not statistically significant (P>0.05); after treatment, the scores of the two groups were both decreased (P<0.05); and that of the observation group was siginificantly lower than the conventional group (P<0.05). The total effective rate of the observation group was 88.57%, which was higher than 71.43% of the conventional group (P<0.05). No death occurred in either of the groups. Conclusion The combination of edaravone and GTLMI can play a protective effect on acute cerebral infarction, which is worth popularizing in clinical use.
KEYWORDS: ginkgo terpene lactones meglumine injection (GTLMI); edaravone; acute cerebral infarction; neurological deficit score

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