病毒性脑炎后继发癫痫的临床特点及药物治疗的临床效果

陈林涛

（陕西省扶风县中医医院神经内科，陕西 宝鸡，722200）

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摘要：

目的 分析病毒性脑炎（VE）后继发癫痫的临床特点，探讨药物治疗的临床效果。方法 回顾性分析2013年1月至2016年5月我院收治的60例VE后继发癫痫患者的临床资料，观察患者的临床症状、癫痫发作形式、持续状态、脑电图及药物治 疗后患者的病情改善情况。结果 VE 后继发癫痫患者临床症状有发热、意识障碍、上呼吸道感染。60例患者中，44 例（73.3%）在 VE发病10 d 内继发癫痫；患者以全面发作为主要发病形式；51例非持续状态患者中，39 例（65.0%）每次发病时间为0～5 min；住院期间发病次数≤5 次的患者占78.3%；脑电图分析以局灶性放电为主，部分患者表现为泛化性放电。经过12个月的随访，60例VE后继发癫痫患者中，好转18例，无效39例，加重3例；5 例 年内发作2～3 次，26 例每周发作，5 例每月发作，1 例每日发作。结论 VE后继发性癫痫主要出现在感染病毒10 d 内，以全面发作最为普遍，多数患者属于非持续状态，脑电图 以局灶放电为主，不同类型药物联合治疗对VE后继发癫痫具有显著疗效。

关键词：

中图分类号：文献标志码：文章编号：0

Clinical characteristics of secondary epilepsy after viral encephalitis and clinical efficacy of drug therapy
CHEN Lin-tao
(Department of Neurology, Traditional Chinese Medicine Hospital of Fufeng County, Baoji 722200, China)

ABSTRACT: Objective To analyze the clinical character istics of secondary epilepsy after viral encephalitis (VE), and investigate the clinical effect of drug therapy. Methods The clinical data of 60 secondary epilepsy after VE patients admitted in our hospital from January 2013 to May 2016 were retrospectively analyzed. The clinical symptoms, epileptic form, persistent state, electroencephalogram and improvement of the patients`` condition after the medicine treatment were observed. Results The clinical symptoms of secondary epilepsy after VE were fever, consciousness disorders and upper respiratory tract infection. In the 60 patients, 44 cases (73.3%) occurred epilepsy within 10 days; the main form of epilepsy was comprehensive. In 51 non persistent patients, the onset time of 39 cases (65.0%) was 0-5 min. During hospitalization, the onset frequency of less than or equal to 5 times accounted for 78.3%. The electroencephalogram mainly focused on focal discharge, and some of the patients showed generalized discharge. After followed up for 12 months, there were 18 cases with improvement, 18 cases with invalidity and 3 cases with aggravation; 5 cases had epilepsy seizure for 2-3 times in one year, 26 cases had epilepsy seizure for per week, 5 cases had epilepsy seizure per months and 1 case had epilepsy seizure every day. Conclusion Secondary epilepsy after VE mainly occur within 10 days of infection. The main form of epilepsy is comprehensive. Most of the secondary epilepsy after VE patients belonging to the non persistent state, and the electroencephalogram mainly focused on focal discharge. The clinical effect of combination of different antiepileptic drugs in the treatment of secondary epilepsy after VE is significant.
KEYWORDS: viral encephalitis (VE); secondary epilepsy after VE; clinical characteristics

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