O型血孕妇血清IgG抗体效价与新生儿溶血病的相关性分析

王都浩，吴敏

（宝鸡市扶风县人民医院，陕西 宝鸡，722299）

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摘要：

目的 分析韵 型血孕妇血清IgG抗体效价水平与新生儿溶血病发病率及严重程度的相关性。方法 选取2012年1月至 2016年12月于我院产科产检并分娩的O型血的孕妇及其新生儿共207例，测定孕妇血清IgG抗体效价，观察新生儿ABO血型分布及新生儿溶血发生率，并分析新生儿发生黄疸、贫血严重程度与血清IgG抗体效价水平的相关性。结果 74例O型 孕妇血清IgG抗A（B）抗体效价水平<1:64，其所生新生儿均未发生新生儿溶血病；133例O型孕妇血清IgG抗A（B）抗体效价水平>1:64，其中47例所产新生儿发生了新生儿溶血病，发生率为35.34%；不同孕妇血清IgG抗A（B）抗体效价水平与其新生儿溶血病发病率比较，差异显著（Z=6.2978，P<0.05）；新生儿溶血病患儿的黄疸及贫血的严重程度与孕妇血清IgG 抗A（B）抗体效价水平没有相关性（P>0.05）。结论 O型孕妇血清IgG抗体效价水平对新生儿溶血病的发生有一定的预测价值，但不能预测新生儿溶血病的病情严重程度。

关键词：O型血孕妇；IgG抗A（B）抗体；新生儿溶血病

中图分类号：R722文献标志码：A文章编号：2096-1413(2017)19-0079-02

Correlation analysis of the serum IgG antibody and hemolytic disease of the newborn in O-type blood pregnant woman
WANG Dou-hao, WU Min
(Fufeng County People``s Hospital, Baoji 722299, China)

ABSTRACT: Objective To analyze the correlation between serum IgG antibody and hemolytic disease of the newborn and its severity in O-type blood pregnant woman. Methods From January 2012 to December 2016, 207 cases of O-type blood pregnant women and their newborns were selected and their serum IgG antibody titer were detected, the distribution of ABO blood group and hemolytic disease incidence in the newborns and the correlation between serum IgG antibody and hemolytic diseases`` severity were observed. Results There was no hemolytic diseases ccurred in 74 cases of O-type pregnant women whose IgG anti-A(B) antibody titer level <1:64; there were 133 cases of O-type pregnant women whose IgG anti-A(B) antibody titer level≥1: 64, of those, 47 cases being hemolytic diseases, the incidence was 35.34%; there were significant differences between the anti-A(B) antibody titer levels and the incidence of neonatal hemolytic disease (Z= 6.2978, P<0.05). There were no significant correlations between the anti-A(B) antibody titer levels and the severity of jaundice, anemia (P>0.05). Conclusion The serum IgG antibody titers has some certain predictive value in the hemolytic disease of the newborn. But it can not predict the severity of neonatal hemolytic disease.
KEYWORDS: O-type blood pregnant woman; IgG anti-A(B) antibody; hemolytic disease of newborn

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