铋剂四联法对幽门螺杆菌阳性胃炎患儿的临床作用

王淑霞

（陕西省府谷县中医医院儿科，陕西 榆林，719499）

浏览次数：81次 下载次数：383次

摘要：

目的 探讨铋剂四联法对幽门螺杆菌阳性胃炎患儿的临床治疗效果。方法 将2013年5月至2016年5月我院收治的幽门螺杆菌阳性胃炎患儿80例按照随机数字表法分为对照组和观察组，每组40例。对照组采用克拉霉素+阿莫西林+奥美拉唑的三联疗法治疗，观察组采用呋喃唑酮+阿莫西林+奥美拉唑+枸缘酸铋钾的四联疗法治疗，对比两组患儿的治疗效果及不良反应发生情况。结果 观察组患儿的治疗总有效率为97.50%，明显高于对照组患儿的72.50%，差异具有统计学意义（P<0.05）；治疗期间，两组患儿均出现不同程度的头昏、便秘、恶心呕吐、上腹不适等不良反应，而两组患儿的不良反应发生率比较，无 显著差异（P>0.05）。结论 铋剂四联法在幽门螺杆菌阳性胃炎患儿的临床治疗中具有较好的应用效果，可在临床治疗中大力推广。

关键词：幽门螺杆菌；胃炎；三联疗法；四联疗法

中图分类号：R725.7 文献标志码：A文章编号：2096-1413(2017)20-0092-02

Clinical effect of bismuth quadruple method on children with helicobacter pylori positive gastritis
WANG Shu-xia
(Department of Pediatrics, Fugu County Hospital of Traditional Chinese Medicine, Yulin 719499, China)

ABSTRACT: Objective To investigate the clinical effect of bismuth quadruple method on children with helicobacter pylori positive gastritis. Methods Eighty cases of children with helicobacter pylori positive gastritis from May 2013 to May 2016 were selected and randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with triple therapy of clarithromycin, amoxicillin and omeprazole, while the observation group was treated with quadruple therapy of omeprazole, amoxicillin, furazolidone and bismuth potassium citrate. The therapeutic effects and adverse reactions of the two groups were compared. Results The total effective rate of the observation group was 97.50%, which was higher than 72.50% of the control group, the difference was statistically significant (P<0.05). During the treatment, the children in the two groups were varying degrees of dizziness, constipation, nausea, vomiting, abdominal discomfort and other adverse reactions, but there were no significant differences in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Bismuth quadruple therapy has good effect in the clinical treatment of children with Helicobacter pylori positive gastritis, which can be widely promoted in clinical treatment.
KEYWORDS: helicobacter pylori; gastritis; triple therapy; quadruple therapy

参考文献：
[1] 张新春,田美莲.铋剂四联与传统三联疗法治疗幽门螺杆菌阳性小儿胃炎的对照研究[J].现代消化及介入诊疗,2016,21(3):480-481.
[2] 邱新萍,王洪,邹济源,等.清利化浊方联合铋剂四联治疗幽门螺杆菌相关慢性非萎缩性胃炎脾胃湿热证40 例临床观察[J].中医杂志,2016,57(5):405-408.
[3] 崔梅花,魏红,雷晓燕,等.含复方尿囊素四联疗法治疗幽门螺杆菌感染慢性胃炎的疗效[J].中华消化杂志,2014,34(5):297-301.
[4] 谢睿,杨晓钟,高成城,等.标准三联加益生菌疗法和铋剂四联方案治疗幽门螺杆菌感染的对照研究[J].山西医科大学学报,2014,45(12):1180-1182.
[5] 王娟芳,高淑娟,朱延宏.含复方尿囊素四联疗法对感染HP慢性胃炎患者的效果研究[J].检验医学与临床,2016,13(15):2208-2210.
[6] 汪楠,王垂杰,李玉锋.抗幽合剂联合四联疗法治疗慢性胃炎合并幽门螺杆菌阳性患者25例临床观察[J].中医杂志,2016,57(2):136-139.
[7] 高文,胡伏莲,成虹,等.国产药物组成的四联疗法对胃炎及十二指肠溃疡患者幽门螺杆菌感染根除效果的前瞻性多中心随机对照研究[J].中华医学杂志,2016,96(4):260-264.
[8] 吴胜,周贤斌.铋剂在以雷贝拉唑为主的四联疗法中治疗幽门螺杆菌阳性的研究[J].中国医师进修杂志,2014,37(1):44-46.