小儿呼吸道感染应用抗病毒药物治疗的不良反应
王淑霞
（陕西省府谷县中医医院儿科，陕西 榆林，719499）
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摘要：
目的 探讨小儿呼吸道感染用抗病毒药物治疗的不良反应。方法 选取2013年12月至2016年12月我院收治的98例小儿呼吸道感染患儿为研究对象，将患儿按照抗病毒药物治疗方法的不同分为A组（病毒唑组，n=50）与B组（更昔洛韦组， n=48）。比较两组患者的不良反应发生情况。结果 A组的不良反应总发生率为10.0%（5/50），与B组的8.3%（4/48）比较，差异无统计学意义（P>0.05）。不良反应包括局部反应、水肿、瘙痒、皮疹、肝功能异常等，经对症处理，症状均消失。结论 病毒唑与更昔洛韦治疗小儿呼吸道感染的不良反应表现多样，需引起高度关注，在用药过程中，应严格把握药物适应证，密切观察患 者反应。
关键词：小儿呼吸道感染；抗病毒药物；更昔洛韦；病毒唑
中图分类号：R725.6文献标志码：A文章编号：2096-1413(2017)21-0092-02
Adverse reactions of antiviral therapy in children with respiratory tract infection
WANG Shu-xia
(Department of Pediatrics, Traditional Chinese Medicine Hospital of Fugu County, Yulin 719499, China)
ABSTRACT: Objective To investigate the adverse reactions of antiviral therapy in children with respiratory tract infection. Methods Ninety-eight cases of children with respiratory tract infection admitted in our hospital from December 2013 to December 2016 were selected. All the children were divided into group A (ribavirin group, n=50) and group B (ganciclovir group, n=50) according to different antiviral therapy methods. The incidence of adverse reactions of the two groups were compared. Results The incidence rate of adverse reaction in group A was 10.0% (5/50), there was no significant difference compared with 8.3% (4/48) in the group B (P>0.05). The adverse reactions included local reactions, edema, pruritus, skin rash, liver dysfunction and so on, and the symptoms disappeared after symptomatic treatment. Conclusion The adverse reactions of ribavirin and ganciclovir in children with respiratory tract infection are various, so we need to pay more attention to it. In the course of medication, we should strictly grasp the indications and observe the patients`` response.
KEYWORDS: respiratory tract infection; antiviral drugs; ganciclovir; ribavirin
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