阿莫西林-克拉维酸钾与阿莫西林的不良反应对比分析

白建平，撒照华，王招娣，闫小玉

（陕西省宝鸡市陇县人民医院药剂科，陕西 宝鸡，721200）

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摘要：

目的 对阿莫西林-克拉维酸钾与阿莫西林的不良反应进行比较。方法 回顾性分析我院应用阿莫西林-克拉维酸钾与阿莫西林治疗的15 628例患者的临床资料，依据患者应用药物的不同分为阿莫西林组7 814例及阿莫西林-克拉维酸钾组 7 814 例，比较应用两种药物的不良反应发生情况。结果 阿莫西林组不良反应发生率（2.07%）高于阿莫西林-克拉维酸钾组（0.72%），不良反应持续时间长于阿莫西林-克拉维酸钾组，不良反应治疗后对原疾病的影响（14.20%）高于阿莫西林-克拉维酸钾组（3.57%），差异有统计学意义（P<>0.05）。结论 与阿莫西林相比，阿莫西林-克拉维酸钾在临床应用中，不良反应较少，且症状持续时间短，对原疾病治疗的影响少，较为安全。

关键词：阿莫西林；阿莫西林-克拉维酸钾；不良反应

中图分类号：R978.1文献标志码：A文章编号：2096-1413(2017)22-0077-02

Comparative analysis of adverse reactions between amoxycillin-clavulanate potassium and amoxicillin
BAI Jian-ping, SA Zhao-hua, WANG Zhao-di, YAN Xiao-yu
(Department of Pharmacy, Long County People``s Hospital, Baoji 721200, China)

ABSTRACT: Objective To compare the adverse reactions betw een amoxycillin -clavulanate potassium and amoxicillin. Methods The clinical data of 15 628 cases of patients in our hospital treated with amoxicillin and amoxicillin-clavulanate potassium were retrospectively analyzed, and the patients were divided into amoxicillin group with 7 814 cases and amoxicillin with clavulanate-clavulanate potassium group with 7 814 cases according to different therapeutic drugs. The adverse reactions of the two drugs were compared. Results The occurrence rate of adverse reactions in the amoxicillin group (2.07%) was higher than that in the clavulanate-clavulanate potassium group (0.72%), and the duration of adverse reactions in the amoxicillin group was longer than that in the amoxicillin-clavulanate potassium group, and the impact of adverse reactions on the original disease after treatment (14.20%) was higher than that of amoxicillin-clavulanate potassium group (3.57%), with significant differences (P<0.05). Conclusion Compared with amoxicillin, the clinical application of amoxycillin-clavulanate potassium has fewer adverse reactions, with short duration of symptoms and less impact on the original disease, which is more secure.
KEYWORDS: amoxicillin; amoxycillin-clavulanate potassium; adverse reactions

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