胺碘酮对老年心律失常患者的作用以及安全性
陈苗利1 ，成百朵2
（1.陕西中医药大学第二附属医院药剂科，陕西 咸阳，712000；2.延安市人民医院药剂科，陕西 延安，716000）
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摘要：
目的 分析并探讨胺碘酮对老年心律失常患者的作用及安全性。方法 选择2011年2月至2016年2月在本院进行治疗的老年心律失常患者200例，随机将其分为对照组（100例）和观察组（100例）。对照组采用普罗帕酮进行治疗，观察组采用胺碘酮进行治疗，对比两组患者的临床疗效和不良反应发生情况。结果 观察组治疗总有效率为94.00%，高于对照组的 76.00%（P<0.05）；观察组恶心、呕吐、口干、头晕、低血压、一过性心率减慢等不良反应发生率均明显低于对照组（P<0.05）。结论 胺碘酮治疗老年心律失常的临床疗效显著，且不良反应较少，是一种安全、有效的治疗方法，值得临床推广应用。
关键词：胺碘酮；心律失常；临床疗效；安全性
中图分类号：R541.7文献标志码：A文章编号：2096-1413(2017)28-0031-02
Effect and safety of amiodarone in elderly patients with arrhythmia
CHEN Miao-li 1, CHENG Bai-duo 2
(1.Department of Pharmacy, the Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000；
2.Department of Pharmacy, Yan``an People``s Hospital, Yan``an 716000，China)
ABSTRACT: Objective To analyze and discuss the effect and safety of amiodarone in elderly patients with arrhythmia. Methods Two hundred cases of elderly patients with arrhythmia in our hospital from February 2011 to February 2016 were enrolled and randomly divided into control group (100 cases) and observation group (100 cases). The control group was treated with propafenone, while the observation group was treated with amiodarone. The clinical efficacy and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 94.00%, which was higher than 76.00% of the control group (P<0.05); the incidence of adverse reactions such as nausea, vomiting,dry mouth, dizziness, hypotension, and slow heart rate in the observation group were significantly lower than those in the control group (P<0.05). Conclusion The amiodarone in the treatment of elderly patients with arrhythmia has significant clinical efficacy, and few adverse reactions, it is a safe and effective treatment method, which is worthy of clinical popularization and application.
KEYWORDS: amiodarone; arrhythmia; clinical efficacy; safety
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