血液灌流与长托宁、阿托品治疗重症有机磷中毒的临床分析

徐曙霞，孙虎

（陕西长安区人民医院，陕西 西安，710100）

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摘要：

目的 分析血液灌流与长托宁、阿托品治疗重症有机磷中毒的效果。方法 将2013年7月至2016年4月我院收治的84例重症有机磷中毒患者按治疗方法分为对照组（n=42）和研究组（n=42）。对照组给予长托宁+阿托品治疗，研究组在对照组基础上联合血液灌注治疗，比较两组治疗效果。结果 对照组的阿托品化时间、中毒症状消失时间、住院时间及胆碱酯酶恢复时间与研究组比较明显更长（P<0.05）；研究组治疗总有效率明显高于对照组（P<0.05）。研究组阿托品中毒率、死亡率均低于对 照组（P<0.05）。结论 重症有机磷中毒采用血液灌流+长托宁+阿托品联合治疗效果显著，可进一步改善临床症状，缩短康复 时间。

关键词：重症有机磷中毒；阿托品；长托宁；血液灌流

中图分类号：R595.4文献标志码：A文章编号：2096-1413(2017)32-0058-02

Clinical analysis of hemoperfusion, penehyclidine hydrochloride and atropine on acute organophosphorus pesticide poisoning
XU Shu-xia, SUN Hu
(Chang`` an District People``s Hospital, Xi``an 710100, China)

ABSTRACT: Objective To analyze the clinical efficacy of hemoperfusion, penehyclidine hydrochloride and atropine on acute organophosphorus pesticide poisoning. Methods A total of 84 cases of patients with acute organophosphorus pesticide poisoning admitted into our hospital from July 2013 to April 2016 were divided into control group and research group according to the treatment methods, with 32 cases in each group. The control group was given penehyclidine hydrochloride and atropine, while the research group was given hemoperfusion on the basis of the control group, and the curative effects were compared between the two groups. Results There were statistically significant differences in the time of atropinization, poisoning disappearance time, hospital stays and CHE recovery time between the two groups (P<0.05). The total effective rate of the research group was higher than that of the control group (P<0.05). The incidence rate of atropine poisoning and mortality in the research group were significantly lower than those in the control group (P<0.05). Conclusion Hemoperfusion,penehyclidine hydrochloride and atropine has better clinical efficacy in the treatment of acute organophosphorus pesticide poisoning, it can further improve patients`` clinical symptoms, shorten recovery time.
KEYWORDS: acute organophosphorus pesticide poisoning; atropine; penehyclidine hydrochloride; hemoperfusion

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