不同剂量右美托咪定复合异丙酚和瑞芬太尼用于腹部手术患者的麻醉效果

卢斌1 ，傅强2 ，张庆华3，刘俊乐4

（1.长安区医院麻醉科，陕西 西安，710100；2.中国人民解放军总医院麻醉手术中心，北京，100853；3.西安市高新医院 麻醉科，陕西 西安，710075；4.福建医科大学附属协和医院麻醉科，福建 福州，350001）

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摘要：

目的 探讨不同剂量右美托咪定复合异丙酚和瑞芬太尼用于腹部手术患者的麻醉的效果。方法 将我院需行腹部手术患者96 例随机分为观察组与对照组，每组48 例。两组患者均于术前30 min 接受右美托咪定复合异丙酚和瑞芬太尼麻醉，观察组右美托咪定剂量为0.8 μg/kg，对照组为0.4 μg/kg。观察两组患者的麻醉效果。结果 观察组患者的苏醒时间、拔管时间及离 开PACU 时间均短于对照组（P<0.05）；观察组不良反应总发生率为16.7%，显著低于对照组的43.8%（P<0.05）。结论 0.8 μg/kg 的右美托咪定复合异丙酚和瑞芬太尼麻醉有助于患者术后恢复，具有较高的安全性，可普遍应用于临床。

关键词：右美托咪定；异丙酚；瑞芬太尼；麻醉

中图分类号：R614文献标志码：A文章编号：2096-1413(2017)32-0060-02

Effects of different doses of dexmedetomidine combined with propofol and remifentanil on anesthesia in patients undergoing abdominal surgery
LU Bin 1, FU Qiang 2, ZHANG Qing-hua 3, LIU Jun-le 4
(1. Department of Anesthesiology, Chang``an District Hospital, Xi``an 710100; 2. Department of Anesthesia Surgery, Chinese PLA General Hospital, Beijing 100853; 3. Department of Anesthesiology, Xi``an Gaoxin Hospital, Xi``an 710075; 4. Department of Anesthesiology,

Fujian Medical University Union Hospital, Fuzhou 350001, China)

ABSTRACT: Objective To investigate the effect of different doses of dexmedetomidine combined with propofol and remifentanil in patients undergoing abdominal surgery. Methods A total of 96 patients with abdominal surgery anesthesia in our hospital were randomly divided into experimental group and control group, with 48 cases in each group. All the patients were treated with dexmedetomidine combined with propofol and remifentanil anesthesia at 30 min before surgery, the experimental group were given 0.8 μg/kg dexmedetomidine, while the control group were given 0.4 μg/kg dexmedetomidine. The anesthetic effects of the two groups were observed. Results The awakening time, extubation time and leaving PACU time in the observation group were shorter than those in the control group (P<0.05). The total adverse reactions rate of the observation group was 16.7%, which was significantly lower than 43.8% of the control group (P<0.05). Conclusion The 0.8 μg/kg of dexmedetomidine complex propofol and remifentanil anesthesia can improve the anesthetic effect and shorten the awakening time, it has highly security, which is worthy of clinical application.
KEYWORDS: dexmedetomidine; propofol; remifentanil; anaesthesia

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