化疗栓塞术联合射频消融治疗肝癌的疗效观察

马宁

（咸阳市第一人民医院，陕西 咸阳，712000）

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摘要：

目的 探讨化疗栓塞术联合射频消融术治疗肝癌的临床疗效。方法 选取2014年5月至2016年4月我院收治的70例原发性肝癌患者为研究对象，随机分为对照组和观察组，各35 例。对照组接受肝动脉灌注化疗栓塞术治疗，观察组患者行肝 动脉灌注化疗栓塞术联合射频消融术治疗。比较两组患者的总有效率、肿瘤血供消失率、肿瘤完全坏死率和不良反应发生情 况。结果 观察组临床总有效率（77.14%）显著高于对照组（51.43%），组间差异显著（P<0.05）。治疗12 个月后，观察组肿瘤血供消失率（80.00%）、肿瘤完全坏死率（74.29%）显著高于对照组（54.29%，31.43%），组间差异显著（P<0.05）。观察组不良反应 发生率（20.00%）略高于对照组（17.14%），组间差异不显著（P>0.05）。结论 原发性肝癌采用肝动脉灌注化疗栓塞术联合射频消融术治疗效果好，不良反应发生率低，值得临床应用。

关键词：肝癌；肝动脉灌注化疗栓塞术；射频消融术

中图分类号：R735.7文献标志码：A文章编号：2096-1413(2017)34-0030-03

Efficacy observation of chemoembolization combined with radio-frequency ablation in the treatment of hepatocellular carcinoma
MA Ning
(the First People``s Hospital of Xianyang City, Xianyang 712000, China)

ABSTRACT: Objective To investigate the clinical efficacy of chemoembolization combined with radio-frequency ablation in the treatment of hepatocellular carcinoma. Methods A total of 70 patients with primary hepatocellular carcinoma admitted in our hospital from May 2014 to April 2016 were selected and randomly divided into control group and observation group, with 35 cases in each group. The control group received hepatic arterial chemoembolization, the patients in the observation group were treated with hepatic arterial chemoembolization combined with radio-frequency ablation. The clinical efficacy rate, disappearance rate of tumor blood supply, tumor necrosis rate and incidence of adverse reactions were compared between the two groups. Results The total clinical efficacy rate of the observation group was 77.14%, which was significantly higher than 51.43% of the control group, there was signlificant difference between the two groups (P<0.05). At 12 months after treatment, the disappearance rate of tumor blood supply (80.00%) and tumor necrosis rate (74.29%) in the observation group were significantly higher than 54.29% and 31.43% in the control group, there were significant differences between the two groups (P<0.05). The incidence of adverse reactions in the observation group was 20.00%, which was slightly higher than 17.14% in the control group, but there was no significant difference between the two groups (P>0.05). Conclusion Hepatic arterial chemoembolization combined with radio-frequency ablation for primary hepatocellular carcinoma has good treatment efficacy and low incidence of adverse reactions, which is worthy of application in clinic.
KEYWORDS: hepatocellular carcinoma; hepatic arterial chemoembolization; radio frequency ablation

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