不同剂量阿托伐他汀在冠心病治疗中的疗效及不良反应

张娜

（渭南市临渭区妇幼保健计划生育服务中心，陕西 渭南，714000）

浏览次数：66次 下载次数：387次

摘要：

目的 探讨不同剂量阿托伐他汀在冠心病治疗中的疗效及不良反应。方法 选取我院2016年9月至2017年1月收治的60例冠心病患者，随机分为试验组与对照组，各30例。试验组患者给予40 mg 阿托伐他汀进行治疗，对照组患者给予20 mg 阿托 伐他汀进行治疗。比较两组患者的临床效果及不良反应发生情况。结果 治疗后，两组患者的TG、TC 及HDL-C 水平明显优 于治疗前，且试验组患者明显优于对照组，差异具有统计学意义（P<0.05）。对照组不良反应总发生率为20.00%，试验组不良 反应总发生率为23.33%，两组不良反应总发生率比较，差异无统计学意义（P>0.05）。结论 不同剂量阿托伐他汀治疗冠心病，剂量越大，治疗效果越明显，而不良反应并未因剂量的增大而增加。

关键词：阿托伐他汀；冠心病；血脂

中图分类号：R541.4文献标志码：A文章编号：2096-1413(2017)34-0049-02

Clinical effect and adverse reaction of different doses of atorvastatin in the treatment of coronary heart disease
ZHANG Na
(Maternal and Child Health Care of Family Planning Service Center in Linwei District, Weinan 714000, China)

ABSTRACT: Objective To evaluate the efficacy and adverse effects of different doses of atorvastatin in the treatment of coronary heart disease. Methods Sixty cases of patients with coronary heart disease admitted in our hospital from September 2016 to January 2017 were selected and randomly divided into experimental group and control group, with 30 cases in each group. The experimental group was treated with 40 mg atorvastatin, and the control group was treated with 20 mg atorvastatin. The clinical effects and adverse reactions were compared between the two groups. Results After treatment, the levels of TG, TC and HDL-C of the two groups were better than those before treatment, and those of the experimental group were better than the control group, the differences were statistically significant (P<0.05). In the control group, the total incidence of adverse reactions was 20.00%, and that in the experimental group was 23.33%, there was no significant difference between the two groups (P>0.05). Conclusion Different doses of atorvastatin in the treatment of coronary heart disease, the greater the dose, the more obvious treatment effect, and the incidence of adverse reactions doesn``t increase with the increasing drug dose.

KEYWORDS: atorvastatin; coronary heart disease; blood lipid

参考文献：
[1] 张群峰.不同剂量阿托伐他汀治疗冠心病高危患者的疗效分析[J]. 内蒙古中医药,2008,27(20):51-52.
[2] 赵春军.不同剂量阿托伐他汀治疗冠心病的临床观察[J].中国医院 用药评价与分析,2015,15(3):367-369.
[3] 高春红.不同剂量阿托伐他汀在冠心病治疗中不良反应的临床分 析[J].中国保健营养,2015,25(9):274-275.
[4] 张健,姚洪森,贺南方,等.对老年冠心病合并高脂血症患者不同剂 量阿托伐他汀治疗的临床研究[J].武警医学,2006,17(2):103-105.
[5] 史晓静,陶贵周.不同剂量阿托伐他汀治疗不稳定型心绞痛的疗效 观察[J].中国当代医药,2009,16(7):53-54.
[6] 惠春,林大专,孙莹.阿托伐他汀致不良反应24 例文献分析[J].中国 药房,2010,21(44):4189-4191.
[7] 王利平.辛伐他汀的不良反应和防治(附35 例报告)[J].中国现代药 物应用,2010,5(7):16-17.
[8] 刘峰.阿托伐他汀治疗冠心病伴高脂血症疗效观察[J].中国实用医 药,2010,26(35):119.
[9] 陈秀兰,黄淑田,苗慧慧,等.不同剂量阿托伐他汀在冠心病治疗中 不良反应的临床分析[J].中西医结合心脑血管病杂志,2010,8(12):1512-1513.
[10] 王星.不同剂量阿托伐他汀治疗冠心病伴高脂血症的临床效果 分析[J].中国继续医学教育,2015,7(19):175-176.
[11] 张艳,陈慧,孙红,等.肠溶阿司匹林在冠心病治疗中致上消化道出 血的相关因素分析[J].医学综述,2010,16(12):1918-1920.
[12] 宋强.不同剂量阿托伐他汀临床应用中不良反应的观察分析.中 国实用医药,2014,9(22):165-166.