艾地苯醌治疗老年脑卒中后抑郁的疗效及其对炎症因子的影响

李亚平，曾熠

（陕西省宝鸡市眉县中医医院神经内科，陕西 宝鸡，722300）

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摘要：

目的 研究艾地苯醌治疗老年脑卒中后抑郁的临床效果及其对炎症因子的影响。方法 选择2013年1月至2016年12月在我院进行诊治的老年脑卒中后抑郁患者90例，随机分为观察组与对照组，每组45例。对照组患者给予神经内科常规治疗，观察组在此基础上给予艾地苯醌治疗。比较两组患者的临床治疗效果和治疗前、治疗后1、3、5、8 周的汉密尔顿抑郁量表 评分及血清炎症因子水平。结果 观察组患者治疗总有效率为88.89%，明显高于对照组的68.89%（P<0.05）；治疗后1、3、5、8周，两组患者的汉密尔顿抑郁量表评分均比治疗前明显降低，且观察组明显低于对照组（P<0.05）；治疗后，两组患者的白介 素-6、肿瘤坏死因子-α及白介素-23 水平均明显降低，且观察组明显低于对照组（P<0.05）。结论 艾地苯醌对老年脑卒中后 抑郁具有显著的临床治疗效果，可以有效改善患者的抑郁程度，并能缓解炎症反应，值得应用推广。

关键词：艾地苯醌；老年脑卒中；抑郁；炎症因子

中图分类号：R743文献标志码：A文章编号：2096-1413(2017)34-0067-02

Effect of idebenone on senile depression patients after stroke and its influence on inflammatory factors
LI Ya-ping, ZENG Yi
(Neurology Department, the Traditional Chinese Medicine Hospital of Mei County, Baoji 722300, China)

ABSTRACT: Objective To investigate the clinical effect of idebenone on senile depression after stroke and its influence on inflammatory factors. Methods A total of 90 cases of senile patients with depression after stroke treated in our hospital from January 2013 to December 2016 were selected and randomly divided into control group and observation group, with 45 cases in each group. The control group was given conventional treatment of neurology department and the observation group was given idebenone. The clinical therapeutic effects, the Hamilton Depression Scale scores before and after treatment for 1, 3, 5 and 8 weeks and the levels of serum inflammatory factors were compared between the two groups. Results The total effective rate of the observation group was 88.89%, which was significantly higher than 68.89% of the control group (P<0.05). After treatment for 1, 3, 5 and 8 weeks, the Hamilton Depression Scale scores of the two groups were significantly lower than those before treatment, and those in the observation group were significantly lower than the control group (P<0.05). After treatment, the levels of interleukin-6, TNF-α and interleukin-23 of the two groups were significantly reduced, and those in the observation group were obviously lower than the control group (P<0.05). Conclusion Idebenone has significant clinical therapeutic effect on senile depression patients after stroke, which can effectively improve the degree of depression and alleviate the inflammatory response, it is worthy of promotion.
KEYWORDS: idebenone; senile stroke; depression; inflammatory factor

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