不同类型癫痫患儿采取丙戊酸钠联合拉莫三嗪治疗的临床疗效对比

郑体厚

（西安市精神卫生中心药剂科，陕西 西安，710061）

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摘要：

目的 观察丙戊酸钠联合拉莫三嗪治疗不同类型癫痫患儿的临床效果。方法 选择我院收治的癫痫患儿127例，根据癫痫 的类型分为四组，分别为部分发作型（PS 组，52 例）、部分发作继发全面发作（SGS 组，37 例）、全面性发作（GS 组，28 例）、 Lennox Gastaut 综合征（LGS 组，10 例）。所有患儿均给予丙戊酸钠联合拉莫三嗪治疗，观察各组患儿的临床治疗效果。结果  SGS 组患儿的完全控制率及治疗总有效率均高于其他三组（P<0.05）；治疗后6、12 个月，四组患儿的癫痫发作次数均少于治 疗前（P<0.05）；治疗期间，在127 例患儿中共出现15 例药物不良反应，发生率为11.81%（15/127），包括乏力7 例、头晕3 例、 恶心3 例、纳差2 例。上述患儿未进行特殊干预，均自行缓解。结论 丙戊酸钠联合拉莫三嗪治疗不同类型癫痫患儿均有不同 程度的效果，均能够显著减少患儿癫痫的发作次数，其中以SGS 疗效最为明显。

关键词：儿童癫痫；丙戊酸钠；拉莫三嗪

中图分类号：R742.1文献标志码：A文章编号：2096-1413(2017)36-0106-02

Clinical effect comparison of sodium valproate combined with lamotrigine in different types of pediatric epilepsy
ZHENG Ti-hou
(Pharmacy Department, Xi``an Mental Health Center, Xi``an 710061, China)

ABSTRACT: Objective To observe the clinical effect of sodium valproate combined with lamotrigine in different types of pediatric epilepsy. Methods A total of 127 children with epilepsy in our hospital were enrolled. According to the type of epilepsy, the patients were divided into four groups: the partial seizures (PS group, 52 cases), partial seizures secondarily generalized seizures (SGS group, 37 cases), generalized seizures (GS group, 28 cases), lennox-gastaut syndrome (LGS group, 10 cases ). All patients were given sodium valproate combined with lamotrigine treatment, the clinical efficacy of each group were observed. Results The complete control rate and total effective rate in the SGS group were higher than those in the other three groups (P<0.05). At 6 and 12 months after treatment, the times of seizures in the four groups were lower than those before treatment (P<0.05). During treatment, a total of 15 cases of adverse drug reactions occurred in 127 patients, the incidence was 11.81% (15/127), including 7 cases of fatigue, 3 cases of dizziness 3 cases of nausea, 2 cases of anorexia. Conclusion Sodium valproate combined with lamotrigine in the treatment of different types of pediatric epilepsy have different degrees of effect, which can significantly reduce the number of episodes of pediatric epilepsy, and the effect for SGS is the best.
KEYWORDS: pediatric epilepsy; sodium valproate; lamotrigine

参考文献：
[1] 中华医学会儿科学分会神经学组.新诊断儿童癫痫的初始单药治 疗专家共识[J].中华儿科杂志,2015,53(10):734-737.
[2] 李乐超,狄晴,张燕芳,等.卡马西平治疗新诊断部分性发作癫痫患 者的预后[J].中华神经科杂志,2013,46(8):524-526.
[3] 薛富英,曾祥发.药物治疗难治性癫痫持续状态的体会[J].广西医 学,2008,14(12):1887-1889.
[4] 李坤艳,罗正葵.抗癫痫药物血药浓度监测研究进展[J].中外健康 文摘,2012,9(32):74-75.
[5] 高俊淑,李娜,陈景红,等.三种抗癫痫药对癫痫患者脑电图的背景 影响比较研究[J].现代生物医学进展,2011,23(23):4485-4487.
[6] 高学军,薛涛,马利,等.拉莫三嗪治疗癫痫的临床研究[J].现代生物 医学进展,2013,13(16):3095-3098.
[7] 吴广德,王树军,高明忠,等.丙戊酸钠联合拉莫三嗪治疗儿童和成 人癫痫的疗效分析[J].中国医药导刊,2015,17(2):159-160.
[8] 宫大勇.丙戊酸钠联合拉莫三嗪治疗癫痫的临床效果[J].中国处方 药,2015,13(1):68.